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Peptide record

TPDB10634

Antibacterial Antifungal Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10634
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GFWTTAAEGLKKFAKAGLASILNPK
Physicochemical Analysis
C123H195N31O32
RDCQHMYV
A
2620.09
10.55
4
1
12
+3
0.34
0.080
82.40
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
209.92
4
Residue Composition
number
5
A
0
R
1
N
0
D
0
C
1
E
0
Q
3
G
0
H
1
I
3
L
4
K
0
M
2
F
1
P
1
S
2
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 5 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 3 K: 4 M: 0 F: 2 P: 1 S: 1 T: 2 W: 1 Y: 0 V: 0
Chemical Descriptors
25
C123H195N31O32
2620.09
10.55
+3
0.34
0.080
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
80 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
weakly active against E. coli (MIC 80 uM) and S-aureus (MIC >80 uM).
Evidence 2 Activity

Activity

MIC
Antifungal
80 µM

Target

Escherichia coli

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
weakly active against E. coli (MIC 80 uM) and S-aureus (MIC >80 uM).
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
105 µM
Hemolytic Cytotoxic
50% Hemolysis | 105 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Host-defense peptides in skin secretions of the tetraploid frog Silurana epitropicalis with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). | Peptides | 2012
Evidence 4 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.