TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10633

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GFWSSALEGLKKFAKGGLEALTNPK

FASTA

>TPDB10633|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=25
GFWSSALEGLKKFAKGGLEALTNPK

Formula C123H193N31O34

Absent Amino Acids RDCQHIMYV

Common Amino Acids GLK

Mass 2650.07

PI 10.16

Basic Residues 4

Acidic Residues 2

Hydrophobic Residues 10

Net Charge +2

Boman Index 2.45

Hydrophobicity -0.252

Aliphatic Index 74.40

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 207.54

Polar Residues 4

number

3

A

0

R

1

N

0

D

0

C

2

E

0

Q

4

G

0

H

0

I

4

L

4

K

0

M

2

F

1

P

2

S

1

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 3 R: 0 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 4 H: 0 I: 0 L: 4 K: 4 M: 0 F: 2 P: 1 S: 2 T: 1 W: 1 Y: 0 V: 0

Length

25

Formula

C123H193N31O34

Mass

2650.07

PI

10.16

Net Charge

+2

Boman Index

2.45

Hydrophobicity

-0.252

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli (MIC 50 uM) and A. baumannii (MIC 12.5 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism A. baumannii

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 50 uM) and A. baumannii (MIC 12.5 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli (MIC 50 uM) and A. baumannii (MIC 12.5 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µM

Target

Target Organism A. baumannii

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against E. coli (MIC 50 uM) and A. baumannii (MIC 12.5 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli (MIC 50 uM) and A. baumannii (MIC 12.5 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12.5 µM

Target

Target Organism A. baumannii

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 50 uM) and A. baumannii (MIC 12.5 uM).