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Peptide record

TPDB10630

Antibacterial Antifungal Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10630
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
MAADIISTIGDLVKLIINTVKKFQK
Physicochemical Analysis
C126H219N31O35S1
RCEHPWY
I
2760.37
10.16
4
2
13
+2
3.61
0.584
140.40
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
2
A
0
R
1
N
2
D
0
C
0
E
1
Q
1
G
0
H
5
I
2
L
4
K
1
M
1
F
0
P
1
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 2 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 5 L: 2 K: 4 M: 1 F: 1 P: 0 S: 1 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
25
C126H219N31O35S1
2760.37
10.16
+2
3.61
0.584
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3 µg/mL

Target

L. pneumophila Lens

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
eumophila ATCC 33216 (sg5), and L. pneumophila ATCC 33215 (sg6). In addition, MIC assays: L. pneumophila Lens (MIC 3 ug/ml) and B. megaterium (MIC 12 ug/ml).
Evidence 2 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

B. megaterium

Source & Reference

dbAMP DRAMP

Other

umophila ATCC 33215 (sg6). In addition, MIC assays: L. pneumophila Lens (MIC 3 ug/ml) and B. megaterium (MIC 12 ug/ml).
Evidence 3 Activity

Activity

MIC
Antifungal
3 µg/mL

Target

L. pneumophila Lens

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
eumophila ATCC 33216 (sg5), and L. pneumophila ATCC 33215 (sg6). In addition, MIC assays: L. pneumophila Lens (MIC 3 ug/ml) and B. megaterium (MIC 12 ug/ml).
Evidence 4 Activity

Activity

MIC
Antifungal
12 µg/mL

Target

B. megaterium

Source & Reference

dbAMP DRAMP Antifungipept

Other

umophila ATCC 33215 (sg6). In addition, MIC assays: L. pneumophila Lens (MIC 3 ug/ml) and B. megaterium (MIC 12 ug/ml).
Evidence 5 Activity

Activity

% Hemolysis
Hemolysis
10 40 62 80 %
[Ref.18339450]10% hemolytic activity at 1.56 µM, 40% hemolytic activity at 6.25 µM, 62% hemolytic activity at 25 µM, 80% hemolytic activity at 50 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Peptides. 2008 Jun 29(6):978-84.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
12 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 12 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of anti-Legionella activity of warnericin RK and delta-lysin I from Staphylococcus warneri. | Peptides | 2008
Evidence 7 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.18339450]10% hemolytic activity at 1.56 µM, 40% hemolytic activity at 6.25 µM, 62% hemolytic activity at 25 µM, 80% hemolytic activity at 50 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2008 Jun 29(6):978-84.
Evidence 8 Hemolysis

Activity

10 40 62 80 %
% Hemolysis
[Ref.18339450]10% hemolytic activity at 1.56 µM, 40% hemolytic activity at 6.25 µM, 62% hemolytic activity at 25 µM, 80% hemolytic activity at 50 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Peptides. 2008 Jun 29(6):978-84.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.