Back to search

Peptide record

TPDB10618

Antibacterial Anticancer Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10618
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GKMKEYFKKFGASFKRRFANLKKRL
Physicochemical Analysis
C144H232N42O31S1
DCQHIPTWV
K
3079.75
11.67
10
1
10
+9
4.80
-1.056
39.20
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
48.38
3
Residue Composition
number
2
A
3
R
1
N
0
D
0
C
1
E
0
Q
2
G
0
H
0
I
2
L
7
K
1
M
4
F
0
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 2 K: 7 M: 1 F: 4 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
25
C144H232N42O31S1
3079.75
11.67
+9
4.80
-1.056
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>36 µM
Hemolytic Cytotoxic
50% Hemolysis | >36 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: a case study in latarcins. | FEBS Lett | 2009
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 50% Hemolysis>36 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
FEBS Lett. 2009 Jul 21 583(14):2425-8.