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Peptide record

TPDB10597

Antibacterial Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10597
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
AWKEKIRKKLKNEIKKKWRKAVIAW
Physicochemical Analysis
C151H252N44O31
DCQGHMFPSTY
K
3179.94
11.34
11
2
11
+9
7.51
-1.216
86.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
16500
518.88
1
Residue Composition
number
3
A
2
R
1
N
0
D
0
C
2
E
0
Q
0
G
0
H
3
I
1
L
9
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 2 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 0 H: 0 I: 3 L: 1 K: 9 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
25
C151H252N44O31
3179.94
11.34
+9
7.51
-1.216
Evidence Records 5 records
Evidence 1 Activity

Activity

25% Cytotoxicity
Toxicity
10 µM
Cytotoxic
25% Cytotoxicity | 10 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48. | J Antibiot (Tokyo) | 2018
Evidence 2 Activity

Activity

20% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
20% Hemolysis | 10 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48. | J Antibiot (Tokyo) | 2018
Evidence 3 Activity

Activity

15% Cytotoxicity
Toxicity
64 µg/mL
Cytotoxic
15% Cytotoxicity | 64 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy. | ACS Pharmacol Transl Sci | 2020
Evidence 4 Activity

Activity

<5% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 128 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy. | ACS Pharmacol Transl Sci | 2020
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis