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Peptide record

TPDB10594

Antibacterial Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10594
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
AGKKTIRQYLKNKIKKKWRKAVIAW
Physicochemical Analysis
C144H243N43O30
DCEHMFPS
K
3056.78
11.80
10
0
11
+10
4.12
-0.980
86.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
12490
408.60
4
Residue Composition
number
3
A
2
R
1
N
0
D
0
C
0
E
1
Q
1
G
0
H
3
I
1
L
8
K
0
M
0
F
0
P
0
S
1
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 3 L: 1 K: 8 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 1 V: 1
Chemical Descriptors
25
C144H243N43O30
3056.78
11.80
+10
4.12
-0.980
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
Antibacterial
0.58 µM

Target

L. donovani

Source & Reference

NA

Other

exhibits leishmanicidal activity against L. donovani (IC50 0.58 uM).
Evidence 2 Activity

Activity

25% Cytotoxicity
Toxicity
10 µM
Cytotoxic
25% Cytotoxicity | 10 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48. | J Antibiot (Tokyo) | 2018
Evidence 3 Activity

Activity

15% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
15% Hemolysis | 10 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48. | J Antibiot (Tokyo) | 2018
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis