TPDB

3D PDB MODEL

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TPDB ID TPDB10588

Activity

Antibacterial Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 25-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.

Sequence

EWKLPDLIINHITLTRRNCFKYRCG

FASTA

>TPDB10588|Antibacterial;Hemolysis;Toxicity|length=25
EWKLPDLIINHITLTRRNCFKYRCG

Formula C139H221N41O35S2

Absent Amino Acids AQMSV

Common Amino Acids RIL

Mass 3090.66

PI 9.70

Basic Residues 6

Acidic Residues 2

Hydrophobic Residues 9

Net Charge +3

Boman Index 3.19

Hydrophobicity -0.456

Aliphatic Index 93.60

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 7115

Absorbance 280nm 230.21

Polar Residues 7

number

0

A

3

R

2

N

1

D

2

C

1

E

0

Q

1

G

1

H

3

I

3

L

2

K

0

M

1

F

1

P

0

S

2

T

1

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 3 N: 2 D: 1 C: 2 E: 1 Q: 0 G: 1 H: 1 I: 3 L: 3 K: 2 M: 0 F: 1 P: 1 S: 0 T: 2 W: 1 Y: 1 V: 0

Length

25

Formula

C139H221N41O35S2

Mass

3090.66

PI

9.70

Net Charge

+3

Boman Index

3.19

Hydrophobicity

-0.456

Evidence 1 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 0.327 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 0.327 | µM | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Gene cloning, expression profiling and anti-microbial assay of Muscin, a new antimicrobial peptide in the housefly (Musca domestica) | Acta Entomologica Sinica | 2015

Evidence 2 Activity

Activity

Activity Endpoint 18% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 54 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

18% Hemolysis | 54 | µM | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Gene cloning, expression profiling and anti-microbial assay of Muscin, a new antimicrobial peptide in the housefly (Musca domestica) | Acta Entomologica Sinica | 2015

Evidence 3 Activity

Activity

Activity Endpoint 19% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 65.4 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

19% Hemolysis | 65.4 | µM | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Gene cloning, expression profiling and anti-microbial assay of Muscin, a new antimicrobial peptide in the housefly (Musca domestica) | Acta Entomologica Sinica | 2015

Evidence 4 Hemolysis

Source & Reference

source HemoPI PD_Hemolysis

Database Source PD_Hemolysis