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Peptide record

TPDB10564

Antibacterial Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10564
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
SKFFRKARKKLGKGLQKIKNVLRKY
Physicochemical Analysis
C141H244N44O30
DCEHMPTW
K
3035.77
12.20
11
0
9
+11
6.21
-1.084
78.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1490
49.08
4
Residue Composition
number
1
A
3
R
1
N
0
D
0
C
0
E
1
Q
2
G
0
H
1
I
3
L
8
K
0
M
2
F
0
P
1
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 1 L: 3 K: 8 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
25
C141H244N44O30
3035.77
12.20
+11
6.21
-1.084
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.8 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

active against Gram- E. coli ATCC 25922 (MIC 0.8 ug/ml), P. aeruginosa ATCC 27853 (MIC 1.0 ug/ml), S. typhimurium ATCC 14028 (MIC 5.0 ug/mL), cli
Evidence 2 Activity

Activity

MIC
Antibacterial
1.0 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

active against Gram- E. coli ATCC 25922 (MIC 0.8 ug/ml), P. aeruginosa ATCC 27853 (MIC 1.0 ug/ml), S. typhimurium ATCC 14028 (MIC 5.0 ug/mL), clinical strain K. pneumoniaeb KBN06903599 (M
Evidence 3 Activity

Activity

MIC
Antibacterial
5.0 ug/mL

Target

S. typhimurium ATCC 14028

Source & Reference

NA

Other

ainst Gram- E. coli ATCC 25922 (MIC 0.8 ug/ml), P. aeruginosa ATCC 27853 (MIC 1.0 ug/ml), S. typhimurium ATCC 14028 (MIC 5.0 ug/mL), clinical strain K. pneumoniaeb KBN06903599 (MIC 4.0 ug/ml), Gram+ S. aureus ATCC 25923 (
Evidence 4 Activity

Activity

MIC
Antibacterial
4.0 µg/mL

Target

K. pneumoniaeb KBN06903599

Source & Reference

NA

Other

sa ATCC 27853 (MIC 1.0 ug/ml), S. typhimurium ATCC 14028 (MIC 5.0 ug/mL), clinical strain K. pneumoniaeb KBN06903599 (MIC 4.0 ug/ml), Gram+ S. aureus ATCC 25923 (MIC 74 ug/ml), B-cereus ATCC 10876 (MIC > 64 ug/ml), S-iniae
Evidence 5 Activity

Activity

MIC
Antibacterial
74 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

14028 (MIC 5.0 ug/mL), clinical strain K. pneumoniaeb KBN06903599 (MIC 4.0 ug/ml), Gram+ S. aureus ATCC 25923 (MIC 74 ug/ml), B-cereus ATCC 10876 (MIC > 64 ug/ml), S-iniae KCTC 3657 (MIC > 64 ug/ml).
Evidence 6 Activity

Activity

3.4±0.5% Hemolysis
Toxicity
2 µg/mL
Hemolytic Cytotoxic
3.4±0.5% Hemolysis | 2 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
The novel cathelicidin of naked mole rats, Hg-CATH, showed potent antimicrobial activity and low cytotoxicity. | Gene | 2018
Evidence 7 Activity

Activity

7.3±0.2% Hemolysis
Toxicity
4 µg/mL
Hemolytic Cytotoxic
7.3±0.2% Hemolysis | 4 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
The novel cathelicidin of naked mole rats, Hg-CATH, showed potent antimicrobial activity and low cytotoxicity. | Gene | 2018
Evidence 8 Activity

Activity

8.2±0.1% Hemolysis
Toxicity
8 µg/mL
Hemolytic Cytotoxic
8.2±0.1% Hemolysis | 8 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
The novel cathelicidin of naked mole rats, Hg-CATH, showed potent antimicrobial activity and low cytotoxicity. | Gene | 2018
Evidence 9 Activity

Activity

9.9±0.2% Hemolysis
Toxicity
16 µg/mL
Hemolytic Cytotoxic
9.9±0.2% Hemolysis | 16 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
The novel cathelicidin of naked mole rats, Hg-CATH, showed potent antimicrobial activity and low cytotoxicity. | Gene | 2018
Evidence 10 Activity

Activity

10.1±0.5% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
10.1±0.5% Hemolysis | 32 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
The novel cathelicidin of naked mole rats, Hg-CATH, showed potent antimicrobial activity and low cytotoxicity. | Gene | 2018
Evidence 11 Activity

Activity

11.4±0.9% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
11.4±0.9% Hemolysis | 64 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
The novel cathelicidin of naked mole rats, Hg-CATH, showed potent antimicrobial activity and low cytotoxicity. | Gene | 2018
Evidence 12 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
The novel cathelicidin of naked mole rats, Hg-CATH, showed potent antimicrobial activity and low cytotoxicity. | Gene | 2018
Evidence 13 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
The novel cathelicidin of naked mole rats, Hg-CATH, showed potent antimicrobial activity and low cytotoxicity. | Gene | 2018
Evidence 14 Activity

Activity

50% Cell death
Toxicity
64 µg/mL
Cytotoxic
50% Cell death | 64 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
The novel cathelicidin of naked mole rats, Hg-CATH, showed potent antimicrobial activity and low cytotoxicity. | Gene | 2018
Evidence 15 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis