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Peptide record

TPDB10562

Antibacterial Antifungal Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10562
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
QSHLSLCRWCCNCCHNKGCGFCCKF
Physicochemical Analysis
C118H178N38O31S8
ADEIMPTYV
C
2881.43
8.10
5
0
5
+3
-0.74
0.028
31.20
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
6000
208.23
13
Residue Composition
number
0
A
1
R
2
N
0
D
8
C
0
E
1
Q
2
G
2
H
0
I
2
L
2
K
0
M
2
F
0
P
2
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 8 E: 0 Q: 1 G: 2 H: 2 I: 0 L: 2 K: 2 M: 0 F: 2 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
25
C118H178N38O31S8
2881.43
8.10
+3
-0.74
0.028
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

disc diffusion method: It inhibits A. baumannii (inhibition area 49.4 mm2), A. salmonicida (55.5 mm2), A. hydrophila (56.91 mm2), P. aeruginosa (50.32 mm2), Gram+ S. aureus (49.26 mm2), E. faecium (40.52 mm2), and fungi C. glabrata (inhibition area 71.24 mm2). Note that a scarmbled peptide also showed reduced inhibition (17.2-27.88 mm2), indicating sequence scrambling did not eliminate the peptide activity.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

CAFPdb Antifungipept

Other

disc diffusion method: It inhibits A. baumannii (inhibition area 49.4 mm2), A. salmonicida (55.5 mm2), A. hydrophila (56.91 mm2), P. aeruginosa (50.32 mm2), Gram+ S. aureus (49.26 mm2), E. faecium (40.52 mm2), and fungi C. glabrata (inhibition area 71.24 mm2). Note that a scarmbled peptide also showed reduced inhibition (17.2-27.88 mm2), indicating sequence scrambling did not eliminate the peptide activity.
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
34.71 µM
Hemolytic Cytotoxic
50% Hemolysis | 34.71 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and expression of the hepcidin gene from brown trout (Salmo trutta) and functional analysis of its synthetic peptide. | Fish Shellfish Immunol | 2019
Evidence 4 Activity

Activity

28.2% Hemolysis
Toxicity
2.17 µM
Hemolytic Cytotoxic
28.2% Hemolysis | 2.17 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and expression of the hepcidin gene from brown trout (Salmo trutta) and functional analysis of its synthetic peptide. | Fish Shellfish Immunol | 2019
Evidence 5 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.