TPDB

3D PDB MODEL

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TPDB ID TPDB10547

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 25-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

EATKCFQWQRNMRKVRGPPVSCIKR

FASTA

>TPDB10547|Antibacterial;Antifungal;Toxicity|length=25
EATKCFQWQRNMRKVRGPPVSCIKR

Formula C130H216N44O33S3

Absent Amino Acids DHLY

Common Amino Acids R

Mass 3019.60

PI 11.40

Basic Residues 7

Acidic Residues 1

Hydrophobic Residues 7

Net Charge +6

Boman Index 6.96

Hydrophobicity -1.012

Aliphatic Index 42.80

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 5625

Absorbance 280nm 186.28

Polar Residues 7

number

1

A

4

R

1

N

0

D

2

C

1

E

2

Q

1

G

0

H

1

I

0

L

3

K

1

M

1

F

2

P

1

S

1

T

1

W

0

Y

2

V

Amino Acid Distribution

A: 1 R: 4 N: 1 D: 0 C: 2 E: 1 Q: 2 G: 1 H: 0 I: 1 L: 0 K: 3 M: 1 F: 1 P: 2 S: 1 T: 1 W: 1 Y: 0 V: 2

Length

25

Formula

C130H216N44O33S3

Mass

3019.60

PI

11.40

Net Charge

+6

Boman Index

6.96

Hydrophobicity

-1.012

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against S. aureus (MBC 12.5 ug/ml), P. aeruginosa (MBC 25 ug/ml), and E. coli (MBC 12.5 ug/ml).

Evidence 2 Activity

Activity

Detail Source Activity Antifungal

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against S. aureus (MBC 12.5 ug/ml), P. aeruginosa (MBC 25 ug/ml), and E. coli (MBC 12.5 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint <10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<10% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Fungicidal Activity of Human Lactoferrin-Derived Peptides Based on the Antimicrobial ?? Region | Int J Antimicrob Agents | 2011