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Peptide record

TPDB10543

Antibacterial Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10543
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GWGSFFKKAAHVAKHVAKAALTHYL
Physicochemical Analysis
C131H196N36O29
RNDCEQIMP
A
2739.22
10.64
7
0
14
+4
0.08
0.108
78.40
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
255.18
3
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
3
H
0
I
2
L
4
K
0
M
2
F
0
P
1
S
1
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 3 I: 0 L: 2 K: 4 M: 0 F: 2 P: 0 S: 1 T: 1 W: 1 Y: 1 V: 2
Chemical Descriptors
25
C131H196N36O29
2739.22
10.64
+4
0.08
0.108
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
50% Hemolysis | 100 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Interaction of pleurocidin and its analogs with phospholipid membrane and their antibacterial activity. | J Pept Res | 2001
Evidence 2 Activity

Activity

37% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
37% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of two glycine residues in positions 13 and 17 of pleurocidin on structure and bacterial cell selectivity. | Protein Pept Lett | 2004
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis