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Peptide record

TPDB10535

Antibacterial Antifungal Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10535
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IWLTALKFLGKNLGKHLAKQQLAKL
Physicochemical Analysis
C135H226N36O30
RDCEMPSYV
L
2833.50
11.12
6
0
13
+5
-0.07
0.148
136.80
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
194.11
4
Residue Composition
number
3
A
0
R
1
N
0
D
0
C
0
E
2
Q
2
G
1
H
1
I
7
L
5
K
0
M
1
F
0
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 2 H: 1 I: 1 L: 7 K: 5 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
25
C135H226N36O30
2833.50
11.12
+5
-0.07
0.148
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.79 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus (MIC 3.79 uM), E. coli (MIC 7.8 uM), yeasts C. neoformans (MIC 13.20 uM) and C. krusei (MIC 26.30 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
7.8 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 3.79 uM), E. coli (MIC 7.8 uM), yeasts C. neoformans (MIC 13.20 uM) and C. krusei (MIC 26.30 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
13.20 µM

Target

C. neoformans

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 3.79 uM), E. coli (MIC 7.8 uM), yeasts C. neoformans (MIC 13.20 uM) and C. krusei (MIC 26.30 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
26.30 µM

Target

C. krusei

Source & Reference

dbAMP DRAMP

Other

st S. aureus (MIC 3.79 uM), E. coli (MIC 7.8 uM), yeasts C. neoformans (MIC 13.20 uM) and C. krusei (MIC 26.30 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
3.79 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus (MIC 3.79 uM), E. coli (MIC 7.8 uM), yeasts C. neoformans (MIC 13.20 uM) and C. krusei (MIC 26.30 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
7.8 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 3.79 uM), E. coli (MIC 7.8 uM), yeasts C. neoformans (MIC 13.20 uM) and C. krusei (MIC 26.30 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
13.20 µM

Target

C. neoformans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 3.79 uM), E. coli (MIC 7.8 uM), yeasts C. neoformans (MIC 13.20 uM) and C. krusei (MIC 26.30 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
26.30 µM

Target

C. krusei

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

st S. aureus (MIC 3.79 uM), E. coli (MIC 7.8 uM), yeasts C. neoformans (MIC 13.20 uM) and C. krusei (MIC 26.30 uM).
Evidence 9 Activity

Activity

Hemolysis
[Ref.19946788]ED50=1.3 × 10−4 M against rabbit erythrocytes

Target

rabbit erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Amino Acids 39:135-144(2010)

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
130 µM
Hemolytic Cytotoxic
50% Hemolysis | 130 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
LyeTx I, a potent antimicrobial peptide from the venom of the spider Lycosa erythrognatha. | Amino Acids | 2010
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
42.54 µM
Hemolytic Cytotoxic
50% Hemolysis | 42.54 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
LyeTxI-b, a Synthetic Peptide Derived From Lycosa erythrognatha Spider Venom, Shows Potent Antibiotic Activity in Vitro and in Vivo. | Front Microbiol | 2018
Evidence 12 Activity

Activity

1% Hemolysis
Toxicity
5.06 µM
Hemolytic Cytotoxic
1% Hemolysis | 5.06 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Shortened derivatives from native antimicrobial peptide LyeTx I: In vitro and in vivo biological activity assessment. | Exp Biol Med (Maywood) | 2021
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
32.35 µM
Hemolytic Cytotoxic
50% Hemolysis | 32.35 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Shortened derivatives from native antimicrobial peptide LyeTx I: In vitro and in vivo biological activity assessment. | Exp Biol Med (Maywood) | 2021
Evidence 14 Activity

Activity

50% Cell death
Toxicity
0.35 µM
Cytotoxic
50% Cell death | 0.35 | µM | target cell: Lund human mesencephalic (LUHMES) cells

Target

Lund human mesencephalic (LUHMES) cells

Source & Reference

NA
DBAASP
Shortened derivatives from native antimicrobial peptide LyeTx I: In vitro and in vivo biological activity assessment. | Exp Biol Med (Maywood) | 2021
Evidence 15 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.19946788]ED50=1.3 × 10−4 M against rabbit erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids 39:135-144(2010)
Evidence 16 Hemolysis

Activity

[Ref.19946788]ED50=1.3 × 10−4 M against rabbit erythrocytes
Hemolysis

Target

rabbit erythrocytes

Source & Reference

APD_complete PD_Hemolysis
Amino Acids 39:135-144(2010)
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.