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Peptide record

TPDB10532

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10532
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia SATPdb Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GWKSVFRKAKKVGKTVGGLALDHYL
Physicochemical Analysis
C129H208N36O31
NCEQIMP
K
2759.29
10.76
7
1
11
+5
2.53
-0.224
89.60
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
253.33
3
Residue Composition
number
2
A
1
R
0
N
1
D
0
C
0
E
0
Q
4
G
1
H
0
I
3
L
5
K
0
M
1
F
0
P
1
S
1
T
1
W
1
Y
3
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 0 L: 3 K: 5 M: 0 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 1 V: 3
Chemical Descriptors
25
C129H208N36O31
2759.29
10.76
+5
2.53
-0.224
Evidence Records 35 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µM

Target

A. salmonicida 99-1

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against A. salmonicida 99-1 (MIC 8 uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. e
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

A. salmonicida 97-4

Source & Reference

dbAMP

Other

Active against A. salmonicida 99-1 (MIC 8 uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 1402
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

S. enterica serovar Typhimurium MS7953s

Source & Reference

dbAMP

Other

Active against A. salmonicida 99-1 (MIC 8 uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32
Evidence 4 Activity

Activity

MIC
Antibacterial
32 µM

Target

S. enterica serovar Typhimurium 14028s

Source & Reference

dbAMP

Other

uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM)
Evidence 5 Activity

Activity

MIC
Antibacterial
4-32 µM

Target

Pseudomonas aeruginosa K799 or Z61

Source & Reference

dbAMP

Other

rovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM), S. epidermidis C621 (MIC 64 uM), methic
Evidence 6 Activity

Activity

MIC
Antibacterial
4-16 µM

Target

Escherichia coli CGSC4908 or UB1005 or DC2

Source & Reference

dbAMP

Other

enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM), S. epidermidis C621 (MIC 64 uM), methicillin-resistant S-aureus C623 (MIC >64 uM), C. al
Evidence 7 Activity

Activity

MIC
Antibacterial
64 µM

Target

Staphylococcus epidermidis C621

Source & Reference

dbAMP

Other

P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM), S. epidermidis C621 (MIC 64 uM), methicillin-resistant S-aureus C623 (MIC >64 uM), C. albicans C627 (MIC 32 uM). Updated
Evidence 8 Activity

Activity

MIC
Antibacterial
32 µM

Target

Candida albicans C627

Source & Reference

dbAMP

Other

6 uM), S. epidermidis C621 (MIC 64 uM), methicillin-resistant S-aureus C623 (MIC >64 uM), C. albicans C627 (MIC 32 uM). Updated 7/2021
Evidence 9 Activity

Activity

MIC
Antifungal
8 µM

Target

A. salmonicida 99-1

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against A. salmonicida 99-1 (MIC 8 uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. e
Evidence 10 Activity

Activity

MIC
Antifungal
8 µM

Target

A. salmonicida 97-4

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against A. salmonicida 99-1 (MIC 8 uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 1402
Evidence 11 Activity

Activity

MIC
Antifungal
4 µM

Target

S. enterica serovar Typhimurium MS7953s

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against A. salmonicida 99-1 (MIC 8 uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32
Evidence 12 Activity

Activity

MIC
Antifungal
32 µM

Target

S. enterica serovar Typhimurium 14028s

Source & Reference

dbAMP CAFPdb Antifungipept

Other

uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM)
Evidence 13 Activity

Activity

MIC
Antifungal
4-32 µM

Target

Pseudomonas aeruginosa K799 or Z61

Source & Reference

dbAMP CAFPdb Antifungipept

Other

rovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM), S. epidermidis C621 (MIC 64 uM), methic
Evidence 14 Activity

Activity

MIC
Antifungal
4-16 µM

Target

Escherichia coli CGSC4908 or UB1005 or DC2

Source & Reference

dbAMP CAFPdb Antifungipept

Other

enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM), S. epidermidis C621 (MIC 64 uM), methicillin-resistant S-aureus C623 (MIC >64 uM), C. al
Evidence 15 Activity

Activity

MIC
Antifungal
64 µM

Target

Staphylococcus epidermidis C621

Source & Reference

dbAMP CAFPdb Antifungipept

Other

P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM), S. epidermidis C621 (MIC 64 uM), methicillin-resistant S-aureus C623 (MIC >64 uM), C. albicans C627 (MIC 32 uM). Updated
Evidence 16 Activity

Activity

MIC
Antifungal
32 µM

Target

Candida albicans C627

Source & Reference

dbAMP CAFPdb Antifungipept

Other

6 uM), S. epidermidis C621 (MIC 64 uM), methicillin-resistant S-aureus C623 (MIC >64 uM), C. albicans C627 (MIC 32 uM). Updated 7/2021
Evidence 17 Activity

Activity

MIC
Antiparasitic
8 µM

Target

A. salmonicida 99-1

Source & Reference

NA

Other

Active against A. salmonicida 99-1 (MIC 8 uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. e
Evidence 18 Activity

Activity

MIC
Antiparasitic
8 µM

Target

A. salmonicida 97-4

Source & Reference

NA

Other

Active against A. salmonicida 99-1 (MIC 8 uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 1402
Evidence 19 Activity

Activity

MIC
Antiparasitic
4 µM

Target

S. enterica serovar Typhimurium MS7953s

Source & Reference

NA

Other

Active against A. salmonicida 99-1 (MIC 8 uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32
Evidence 20 Activity

Activity

MIC
Antiparasitic
32 µM

Target

S. enterica serovar Typhimurium 14028s

Source & Reference

NA

Other

uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM)
Evidence 21 Activity

Activity

MIC
Antiparasitic
4-32 µM

Target

Pseudomonas aeruginosa K799 or Z61

Source & Reference

NA

Other

rovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM), S. epidermidis C621 (MIC 64 uM), methic
Evidence 22 Activity

Activity

MIC
Antiparasitic
4-16 µM

Target

Escherichia coli CGSC4908 or UB1005 or DC2

Source & Reference

NA

Other

enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM), S. epidermidis C621 (MIC 64 uM), methicillin-resistant S-aureus C623 (MIC >64 uM), C. al
Evidence 23 Activity

Activity

MIC
Antiparasitic
64 µM

Target

Staphylococcus epidermidis C621

Source & Reference

NA

Other

P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM), S. epidermidis C621 (MIC 64 uM), methicillin-resistant S-aureus C623 (MIC >64 uM), C. albicans C627 (MIC 32 uM). Updated
Evidence 24 Activity

Activity

MIC
Antiparasitic
32 µM

Target

Candida albicans C627

Source & Reference

NA

Other

6 uM), S. epidermidis C621 (MIC 64 uM), methicillin-resistant S-aureus C623 (MIC >64 uM), C. albicans C627 (MIC 32 uM). Updated 7/2021
Evidence 25 Activity

Activity

MIC
Antiviral
8 µM

Target

A. salmonicida 99-1

Source & Reference

NA

Other

Active against A. salmonicida 99-1 (MIC 8 uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. e
Evidence 26 Activity

Activity

MIC
Antiviral
8 µM

Target

A. salmonicida 97-4

Source & Reference

NA

Other

Active against A. salmonicida 99-1 (MIC 8 uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 1402
Evidence 27 Activity

Activity

MIC
Antiviral
4 µM

Target

S. enterica serovar Typhimurium MS7953s

Source & Reference

NA

Other

Active against A. salmonicida 99-1 (MIC 8 uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32
Evidence 28 Activity

Activity

MIC
Antiviral
32 µM

Target

S. enterica serovar Typhimurium 14028s

Source & Reference

NA

Other

uM), A. salmonicida 97-4 (MIC 8 uM), S. enterica serovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM)
Evidence 29 Activity

Activity

MIC
Antiviral
4-32 µM

Target

Pseudomonas aeruginosa K799 or Z61

Source & Reference

NA

Other

rovar Typhimurium MS7953s (MIC 4 uM), S. enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM), S. epidermidis C621 (MIC 64 uM), methic
Evidence 30 Activity

Activity

MIC
Antiviral
4-16 µM

Target

Escherichia coli CGSC4908 or UB1005 or DC2

Source & Reference

NA

Other

enterica serovar Typhimurium 14028s (MIC 32 uM), P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM), S. epidermidis C621 (MIC 64 uM), methicillin-resistant S-aureus C623 (MIC >64 uM), C. al
Evidence 31 Activity

Activity

MIC
Antiviral
64 µM

Target

Staphylococcus epidermidis C621

Source & Reference

NA

Other

P. aeruginosa K799 or Z61 (MIC 4-32 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4-16 uM), S. epidermidis C621 (MIC 64 uM), methicillin-resistant S-aureus C623 (MIC >64 uM), C. albicans C627 (MIC 32 uM). Updated
Evidence 32 Activity

Activity

MIC
Antiviral
32 µM

Target

Candida albicans C627

Source & Reference

NA

Other

6 uM), S. epidermidis C621 (MIC 64 uM), methicillin-resistant S-aureus C623 (MIC >64 uM), C. albicans C627 (MIC 32 uM). Updated 7/2021
Evidence 33 Activity

Activity

50% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 34 Activity

Activity

>10% Killing
Toxicity
5 µM
Cytotoxic
>10% Killing | 5 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 35 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.