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Peptide record

TPDB10528

Antibacterial Anticancer Antifungal Antiparasitic standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10528
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
DTHFPICIFCCGCCHRSKCGMCCKT
Physicochemical Analysis
C113H178N34O31S9
ANEQLWYV
C
2797.41
7.86
5
1
5
+2
1.79
0.388
31.20
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
500
17.87
11
Residue Composition
number
0
A
1
R
0
N
1
D
8
C
0
E
0
Q
2
G
2
H
2
I
0
L
2
K
1
M
2
F
1
P
1
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 8 E: 0 Q: 0 G: 2 H: 2 I: 2 L: 0 K: 2 M: 1 F: 2 P: 1 S: 1 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
25
C113H178N34O31S9
2797.41
7.86
+2
1.79
0.388
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5.38 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ML35p, P. aeruginosa, S. aureus (MIC 5.38ug/ml), S. epidermidis, group B Streptococcus, and fungus C. albicans. Also, Gram-positive B. me
Evidence 2 Activity

Activity

IC50
Antibacterial
40 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

rmidis, group B Streptococcus, and fungus C. albicans. Also, Gram-positive B. megaterium, B. subtilis (IC50 40ug/ml), M. luteus, S. carnosus, and Gram-negative N. cinerea as well as the yeast S. cerevisiae
Evidence 3 Activity

Activity

IC50
Antibacterial
50 µg/mL

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

(IC50 40ug/ml), M. luteus, S. carnosus, and Gram-negative N. cinerea as well as the yeast S. cerevisiae (IC50 50ug/ml). Also inhibits S. aureus and B. cereus ( Sadr et al., 2017 ).
Evidence 4 Activity

Activity

MIC
Antifungal
5.38 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ML35p, P. aeruginosa, S. aureus (MIC 5.38ug/ml), S. epidermidis, group B Streptococcus, and fungus C. albicans. Also, Gram-positive B. me
Evidence 5 Activity

Activity

IC50
Antifungal
40 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

rmidis, group B Streptococcus, and fungus C. albicans. Also, Gram-positive B. megaterium, B. subtilis (IC50 40ug/ml), M. luteus, S. carnosus, and Gram-negative N. cinerea as well as the yeast S. cerevisiae
Evidence 6 Activity

Activity

IC50
Antifungal
50 µg/mL

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(IC50 40ug/ml), M. luteus, S. carnosus, and Gram-negative N. cinerea as well as the yeast S. cerevisiae (IC50 50ug/ml). Also inhibits S. aureus and B. cereus ( Sadr et al., 2017 ).
Evidence 7 Activity

Activity

MIC
Antiparasitic
5.38 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli ML35p, P. aeruginosa, S. aureus (MIC 5.38ug/ml), S. epidermidis, group B Streptococcus, and fungus C. albicans. Also, Gram-positive B. me
Evidence 8 Activity

Activity

IC50
Antiparasitic
40 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

rmidis, group B Streptococcus, and fungus C. albicans. Also, Gram-positive B. megaterium, B. subtilis (IC50 40ug/ml), M. luteus, S. carnosus, and Gram-negative N. cinerea as well as the yeast S. cerevisiae
Evidence 9 Activity

Activity

IC50
Antiparasitic
50 µg/mL

Target

S. cerevisiae

Source & Reference

DRAMP

Other

(IC50 40ug/ml), M. luteus, S. carnosus, and Gram-negative N. cinerea as well as the yeast S. cerevisiae (IC50 50ug/ml). Also inhibits S. aureus and B. cereus ( Sadr et al., 2017 ).