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Peptide record

TPDB10527

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

25 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10527

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb i2APP AVPpred-BWR APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GILKKFMLHRGTKVYKMRTLSKRSH

FASTA

>TPDB10527|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=25
GILKKFMLHRGTKVYKMRTLSKRSH

Formula C135H231N43O31S2

Absent Amino Acids ANDCEQPW

Common Amino Acids K

Mass 3016.71

PI 12.17

Basic Residues 10

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +8

Boman Index 5.41

Hydrophobicity -0.712

Aliphatic Index 74.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 49.39

Polar Residues 5

number

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 2 I: 1 L: 3 K: 5 M: 2 F: 1 P: 0 S: 2 T: 2 W: 0 Y: 1 V: 1

Length

Formula

C135H231N43O31S2

Mass

3016.71

12.17

Net Charge

Boman Index

5.41

Hydrophobicity

-0.712

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5 ug/mL

Target

Target Organism Escherichia coli ATCC25629

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against normal and resistant E. coli ATCC25629 (MIC 5 ug/mL), normal and resistant S. aureus ATCC2576 (MIC 0.5-1.0 ug/mL), normal and resistant B. dys

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5-1.0 ug/mL

Target

Target Organism Staphylococcus aureus ATCC2576

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against normal and resistant E. coli ATCC25629 (MIC 5 ug/mL), normal and resistant S. aureus ATCC2576 (MIC 0.5-1.0 ug/mL), normal and resistant B. dysenteriae ATCC 2932 (MIC 2.5-5.0), and C. albicans ATCC 3007 (

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7.5 ug/mL

Target

Target Organism Candida albicans ATCC 3007

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

576 (MIC 0.5-1.0 ug/mL), normal and resistant B. dysenteriae ATCC 2932 (MIC 2.5-5.0), and C. albicans ATCC 3007 (MIC 7.5 ug/mL). it caused 55.2% histamine release from mast cells at 100 ug/ml.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5 ug/mL

Target

Target Organism Escherichia coli ATCC25629

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against normal and resistant E. coli ATCC25629 (MIC 5 ug/mL), normal and resistant S. aureus ATCC2576 (MIC 0.5-1.0 ug/mL), normal and resistant B. dys

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.5-1.0 ug/mL

Target

Target Organism Staphylococcus aureus ATCC2576

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 7.5 ug/mL

Target

Target Organism Candida albicans ATCC 3007

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

576 (MIC 0.5-1.0 ug/mL), normal and resistant B. dysenteriae ATCC 2932 (MIC 2.5-5.0), and C. albicans ATCC 3007 (MIC 7.5 ug/mL). it caused 55.2% histamine release from mast cells at 100 ug/ml.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 5 ug/mL

Target

Target Organism Escherichia coli ATCC25629

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against normal and resistant E. coli ATCC25629 (MIC 5 ug/mL), normal and resistant S. aureus ATCC2576 (MIC 0.5-1.0 ug/mL), normal and resistant B. dys

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.5-1.0 ug/mL

Target

Target Organism Staphylococcus aureus ATCC2576

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 7.5 ug/mL

Target

Target Organism Candida albicans ATCC 3007

Source & Reference

Database Source DRAMP

Other

Evidence Text

576 (MIC 0.5-1.0 ug/mL), normal and resistant B. dysenteriae ATCC 2932 (MIC 2.5-5.0), and C. albicans ATCC 3007 (MIC 7.5 ug/mL). it caused 55.2% histamine release from mast cells at 100 ug/ml.

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 5 ug/mL

Target

Target Organism Escherichia coli ATCC25629

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against normal and resistant E. coli ATCC25629 (MIC 5 ug/mL), normal and resistant S. aureus ATCC2576 (MIC 0.5-1.0 ug/mL), normal and resistant B. dys

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.5-1.0 ug/mL

Target

Target Organism Staphylococcus aureus ATCC2576

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 7.5 ug/mL

Target

Target Organism Candida albicans ATCC 3007

Source & Reference

Database Source DRAMP

Other

Evidence Text

576 (MIC 0.5-1.0 ug/mL), normal and resistant B. dysenteriae ATCC 2932 (MIC 2.5-5.0), and C. albicans ATCC 3007 (MIC 7.5 ug/mL). it caused 55.2% histamine release from mast cells at 100 ug/ml.

Evidence 13 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 7 %

Hemolysis Raw

[Ref.19716842]32 ± 7% hemolytic activity at 50 µg/ml against human red blood cells

Target

RBC Target human red blood cells

Source & Reference

Database Source Hemolytik APD_complete APD_hemolytic PD_Hemolysis

Source DRAMP4

Reference

Toxicon. 2010 Feb-Mar 55(2-3):274-279.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 14 Activity

Activity

Activity Endpoint 32% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

32% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Two novel antimicrobial peptides from centipede venoms. | Toxicon | 2010

Evidence 15 Activity

Activity

Activity Endpoint 37% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

37% Hemolysis | 50 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Two novel antimicrobial peptides from centipede venoms. | Toxicon | 2010

Evidence 16 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.19716842]32 ± 7% hemolytic activity at 50 µg/ml against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Toxicon. 2010 Feb-Mar 55(2-3):274-279.

Evidence 17 Hemolysis

Activity

Activity Measurement 7 %

Activity Endpoint % Hemolysis

Hemolysis Raw

[Ref.19716842]32 ± 7% hemolytic activity at 50 µg/ml against human red blood cells

Detail Source Activity Hemolysis

Target

RBC Target human red blood cells

Source & Reference

source APD_complete APD_hemolytic HemoPI PD_Hemolysis

Reference

Toxicon. 2010 Feb-Mar 55(2-3):274-279.

Source DRAMP4

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.