Back to search

Peptide record

TPDB10505

Antibacterial Antifungal Hemolysis Toxicity standard

25 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10505

Activity

Antibacterial Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia CAFPdb dbAMP PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 25-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.

Sequence

GIGGALLSFGKSALKGLAKGLAEHF

FASTA

>TPDB10505|Antibacterial;Antifungal;Hemolysis;Toxicity|length=25
GIGGALLSFGKSALKGLAKGLAEHF

Formula C113H184N30O30

Absent Amino Acids RNDCQMPTWYV

Common Amino Acids G

Mass 2442.89

PI 10.32

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 12

Net Charge +2

Boman Index 0.22

Hydrophobicity 0.556

Aliphatic Index 109.60

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

Amino Acid Distribution

A: 4 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 6 H: 1 I: 1 L: 5 K: 3 M: 0 F: 2 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C113H184N30O30

Mass

2442.89

10.32

Net Charge

Boman Index

0.22

Hydrophobicity

0.556

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.6 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against S. aureus (MIC 1.6 uM), MRSA (MIC 6.6 uM), E. coli (MIC 6.6 uM), P. aeruginosa (MIC 26.2 uM), and C. albicans (M

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.6 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against S. aureus (MIC 1.6 uM), MRSA (MIC 6.6 uM), E. coli (MIC 6.6 uM), P. aeruginosa (MIC 26.2 uM), and C. albicans (MIC 1.6 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 26.2 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against S. aureus (MIC 1.6 uM), MRSA (MIC 6.6 uM), E. coli (MIC 6.6 uM), P. aeruginosa (MIC 26.2 uM), and C. albicans (MIC 1.6 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.6 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

s (MIC 1.6 uM), MRSA (MIC 6.6 uM), E. coli (MIC 6.6 uM), P. aeruginosa (MIC 26.2 uM), and C. albicans (MIC 1.6 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.6 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP CAFPdb

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against S. aureus (MIC 1.6 uM), MRSA (MIC 6.6 uM), E. coli (MIC 6.6 uM), P. aeruginosa (MIC 26.2 uM), and C. albicans (M

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.6 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

Active against S. aureus (MIC 1.6 uM), MRSA (MIC 6.6 uM), E. coli (MIC 6.6 uM), P. aeruginosa (MIC 26.2 uM), and C. albicans (MIC 1.6 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 26.2 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

Active against S. aureus (MIC 1.6 uM), MRSA (MIC 6.6 uM), E. coli (MIC 6.6 uM), P. aeruginosa (MIC 26.2 uM), and C. albicans (MIC 1.6 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.6 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

s (MIC 1.6 uM), MRSA (MIC 6.6 uM), E. coli (MIC 6.6 uM), P. aeruginosa (MIC 26.2 uM), and C. albicans (MIC 1.6 uM).

Evidence 9 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 64 | µg/mL | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The synergistic antimicrobial effects of novel bombinin and bombinin H peptides from the skin secretion of Bombina orientalis | Biosci Rep | 2017

Evidence 10 Activity

Activity

Activity Endpoint 50% Cell death

Detail Source Activity Toxicity

Activity Measurement 94.32±0.72 µM

Toxicity Type Cytotoxic

Toxicity Raw

50% Cell death | 94.32±0.72 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Target Cell Human microvascular endothelial cells HMEC-1

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The synergistic antimicrobial effects of novel bombinin and bombinin H peptides from the skin secretion of Bombina orientalis | Biosci Rep | 2017

Evidence 11 Hemolysis

Source & Reference

source PD_Hemolysis

Database Source PD_Hemolysis