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Peptide record

TPDB10497

Antibacterial Anticancer Antifungal Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10497
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GIGSAILSAGKSIIKGLAKGLAEHF
Physicochemical Analysis
C111H188N30O31
RNDCQMPTWYV
G
2438.90
10.32
4
1
12
+2
1.66
0.664
125.20
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
1
E
0
Q
5
G
1
H
4
I
3
L
3
K
0
M
1
F
0
P
3
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 5 H: 1 I: 4 L: 3 K: 3 M: 0 F: 1 P: 0 S: 3 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
25
C111H188N30O31
2438.90
10.32
+2
1.66
0.664
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
26 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli (MIC 26 uM), S. aureus (MIC 26 uM), C. albicans (MIC 52 uM). MBC = MIC. It also inhibited human hepat
Evidence 2 Activity

Activity

MIC
Antibacterial
26 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Active against E. coli (MIC 26 uM), S. aureus (MIC 26 uM), C. albicans (MIC 52 uM). MBC = MIC. It also inhibited human hepatoma cell lines (Hep G2,
Evidence 3 Activity

Activity

MIC
Antibacterial
52 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

Active against E. coli (MIC 26 uM), S. aureus (MIC 26 uM), C. albicans (MIC 52 uM). MBC = MIC. It also inhibited human hepatoma cell lines (Hep G2, SK-HEP-1 and Huh7) with
Evidence 4 Activity

Activity

MIC
Antifungal
26 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli (MIC 26 uM), S. aureus (MIC 26 uM), C. albicans (MIC 52 uM). MBC = MIC. It also inhibited human hepat
Evidence 5 Activity

Activity

MIC
Antifungal
26 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 26 uM), S. aureus (MIC 26 uM), C. albicans (MIC 52 uM). MBC = MIC. It also inhibited human hepatoma cell lines (Hep G2,
Evidence 6 Activity

Activity

MIC
Antifungal
52 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 26 uM), S. aureus (MIC 26 uM), C. albicans (MIC 52 uM). MBC = MIC. It also inhibited human hepatoma cell lines (Hep G2, SK-HEP-1 and Huh7) with
Evidence 7 Activity

Activity

2.89% Hemolysis
Toxicity
26.3 µM
Hemolytic Cytotoxic
2.89% Hemolysis | 26.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Molecular characterization and bioactivity evaluation of two novel bombinin peptides from the skin secretion of Oriental fire-bellied toad, Bombina orientalis. | Amino Acids | 2017
Evidence 8 Activity

Activity

38.05% Hemolysis
Toxicity
52.5 µM
Hemolytic Cytotoxic
38.05% Hemolysis | 52.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Molecular characterization and bioactivity evaluation of two novel bombinin peptides from the skin secretion of Oriental fire-bellied toad, Bombina orientalis. | Amino Acids | 2017
Evidence 9 Activity

Activity

% Hemolysis
Toxicity
2.89 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 2.89% Hemolysis=26.3µM Human erythrocytes=38.05% Hemolysis=52.5µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2018 Feb 50(2):241-253