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Peptide record

TPDB10495

Antibacterial Antifungal Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10495
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb PD_Hemolysis
standard
No
A 25-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RIKRFWPVVIRTVVAGYNLYRAIKK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C145H236N42O30
DCEQHMS
RV
3047.73
11.99
7
0
14
+7
1.60
0.044
116.80
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
8480
2.78
4
Residue Composition
number
2
A
4
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
1
L
3
K
0
M
1
F
1
P
0
S
1
T
1
W
2
Y
4
V
Amino Acid Distribution
A: 2 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 3 M: 0 F: 1 P: 1 S: 0 T: 1 W: 1 Y: 2 V: 4
Chemical Descriptors
25 reviewed residue count
C145H236N42O30 sequence-only estimate (linear, free termini)
3047.73 sequence-only estimate (linear, free termini)
11.99 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
1.60 sequence-only estimate (linear, free termini)
0.044 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

28% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
28% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1 | Nat Prod Bioprospect | 2012
Evidence 2 Activity

Activity

21% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
21% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1 | Nat Prod Bioprospect | 2012
Evidence 3 Activity

Activity

16% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
16% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1 | Nat Prod Bioprospect | 2012
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis