TPDB

3D PDB MODEL

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TPDB ID TPDB10495

Activity

Antibacterial Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 25-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

RIKRFWPVVIRTVVAGYNLYRAIKK

FASTA

>TPDB10495|Antibacterial;Antifungal;Hemolysis;Toxicity|length=25
RIKRFWPVVIRTVVAGYNLYRAIKK

Formula C145H236N42O30

Absent Amino Acids DCEQHMS

Common Amino Acids RV

Mass 3047.73

PI 11.99

Basic Residues 7

Acidic Residues 0

Hydrophobic Residues 14

Net Charge +7

Boman Index 0.82

Hydrophobicity 0.044

Aliphatic Index 116.80

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 8480

Absorbance 280nm 278.24

Polar Residues 4

number

2

A

4

R

1

N

0

D

0

C

0

E

0

Q

1

G

0

H

3

I

1

L

3

K

0

M

1

F

1

P

0

S

1

T

1

W

2

Y

4

V

Amino Acid Distribution

A: 2 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 3 M: 0 F: 1 P: 1 S: 0 T: 1 W: 1 Y: 2 V: 4

Length

25

Formula

C145H236N42O30

Mass

3047.73

PI

11.99

Net Charge

+7

Boman Index

0.82

Hydrophobicity

0.044

Evidence 1 Activity

Activity

Activity Endpoint 28% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

28% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1 | Nat Prod Bioprospect | 2012

Evidence 2 Activity

Activity

Activity Endpoint 21% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

21% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1 | Nat Prod Bioprospect | 2012

Evidence 3 Activity

Activity

Activity Endpoint 16% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

16% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1 | Nat Prod Bioprospect | 2012

Evidence 4 Hemolysis

Source & Reference

source PD_Hemolysis

Database Source PD_Hemolysis