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Peptide record

TPDB10494

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10494
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GVWSTILGGLKKFAKGGLDAIVNPK
Physicochemical Analysis
C120H197N31O31
RCEQHMY
G
2570.07
10.55
4
1
11
+3
0.90
0.264
109.20
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
214.00
3
Residue Composition
number
2
A
0
R
1
N
1
D
0
C
0
E
0
Q
5
G
0
H
2
I
3
L
4
K
0
M
1
F
1
P
1
S
1
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 2 L: 3 K: 4 M: 0 F: 1 P: 1 S: 1 T: 1 W: 1 Y: 0 V: 2
Chemical Descriptors
25
C120H197N31O31
2570.07
10.55
+3
0.90
0.264
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E. coli (MIC 2-4 uM), P. aeruginosa (MIC 16 uM), Gram+ S. aureus (MIC 8-16 uM), M. luteus (MIC 0.5 uM), yeast
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 2-4 uM), P. aeruginosa (MIC 16 uM), Gram+ S. aureus (MIC 8-16 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), a
Evidence 3 Activity

Activity

MIC
Antibacterial
8-16 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 2-4 uM), P. aeruginosa (MIC 16 uM), Gram+ S. aureus (MIC 8-16 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 2.4
Evidence 4 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

M. luteus

Source & Reference

dbAMP

Other

nst Gram- E. coli (MIC 2-4 uM), P. aeruginosa (MIC 16 uM), Gram+ S. aureus (MIC 8-16 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 2.4 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µM

Target

S. cerevisiae

Source & Reference

dbAMP

Other

, P. aeruginosa (MIC 16 uM), Gram+ S. aureus (MIC 8-16 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 2.4 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
2-4 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- E. coli (MIC 2-4 uM), P. aeruginosa (MIC 16 uM), Gram+ S. aureus (MIC 8-16 uM), M. luteus (MIC 0.5 uM), yeast
Evidence 7 Activity

Activity

MIC
Antifungal
16 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 2-4 uM), P. aeruginosa (MIC 16 uM), Gram+ S. aureus (MIC 8-16 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), a
Evidence 8 Activity

Activity

MIC
Antifungal
8-16 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 2-4 uM), P. aeruginosa (MIC 16 uM), Gram+ S. aureus (MIC 8-16 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 2.4
Evidence 9 Activity

Activity

MIC
Antifungal
0.5 µM

Target

M. luteus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

nst Gram- E. coli (MIC 2-4 uM), P. aeruginosa (MIC 16 uM), Gram+ S. aureus (MIC 8-16 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 2.4 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
8 µM

Target

S. cerevisiae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

, P. aeruginosa (MIC 16 uM), Gram+ S. aureus (MIC 8-16 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 2.4 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
2-4 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram- E. coli (MIC 2-4 uM), P. aeruginosa (MIC 16 uM), Gram+ S. aureus (MIC 8-16 uM), M. luteus (MIC 0.5 uM), yeast
Evidence 12 Activity

Activity

MIC
Antiparasitic
16 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 2-4 uM), P. aeruginosa (MIC 16 uM), Gram+ S. aureus (MIC 8-16 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), a
Evidence 13 Activity

Activity

MIC
Antiparasitic
8-16 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 2-4 uM), P. aeruginosa (MIC 16 uM), Gram+ S. aureus (MIC 8-16 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 2.4
Evidence 14 Activity

Activity

MIC
Antiparasitic
0.5 µM

Target

M. luteus

Source & Reference

dbAMP 3.0

Other

nst Gram- E. coli (MIC 2-4 uM), P. aeruginosa (MIC 16 uM), Gram+ S. aureus (MIC 8-16 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 2.4 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
8 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0

Other

, P. aeruginosa (MIC 16 uM), Gram+ S. aureus (MIC 8-16 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 2.4 uM).
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
50% Hemolysis | 64 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 17 Activity

Activity

IC50
Toxicity
8 µM
Cytotoxic
IC50 | 8 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 18 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.