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Peptide record

TPDB10491

Antibacterial Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10491
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
MMRVMRRKTKVIWEKKDFIGLYSID
Physicochemical Analysis
C142H235N39O35S3
ANCQHP
K
3144.85
10.62
7
3
12
+4
5.19
-0.380
85.60
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
222.27
3
Residue Composition
number
0
A
3
R
0
N
2
D
0
C
1
E
0
Q
1
G
0
H
3
I
1
L
4
K
3
M
1
F
0
P
1
S
1
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 2 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 4 M: 3 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 1 V: 2
Chemical Descriptors
25
C142H235N39O35S3
3144.85
10.62
+4
5.19
-0.380
Evidence Records 4 records
Evidence 1 Activity

Activity

8% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
8% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Catesbeianin-1, a novel antimicrobial peptide isolated from the skin of Lithobates catesbeianus (American bullfrog). | Biotechnol Lett | 2017
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
300 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 300 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Catesbeianin-1, a novel antimicrobial peptide isolated from the skin of Lithobates catesbeianus (American bullfrog). | Biotechnol Lett | 2017
Evidence 3 Activity

Activity

15% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
15% Cytotoxicity | 100 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Catesbeianin-1, a novel antimicrobial peptide isolated from the skin of Lithobates catesbeianus (American bullfrog). | Biotechnol Lett | 2017
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28258530] 0% hemolysis at 0 µg/ml , hemolysis 3% at 25 µg/ml , 7% hemolysis at 50 µg/ml , 8% hemolysis at 100 µg/ml , 35% hemolysis at 200 µg/ml , 50% hemolysis at 300 µg/ml , 85% hemolysis at 400 µg/ml , 95% hemolysis at 500 µg/ml against human red blood cells | Cytotoxicity: [Ref.28258530] The cell viability of HEK293T cells is 102%, 103%, 103%, 100%, 98% and 85% at peptide concentrations of 0, 20, 40, 60, 80 and 100 µg/ml. ##The cell viability of HL-7200 cells is 107%, 106%, 99%, 95% and 88% at peptide concentrations of 0,

Target

erythrocytes

Source & Reference

NA
DRAMP
Biotechnol Lett. 2017 Jun 39(6):897-903. doi: 10.1007/s10529-017-2312-7.