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Peptide record

TPDB10478

Antibacterial Anticancer Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10478
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
VCRKPVVCRKPVVCRKPVVCRKPV
Physicochemical Analysis
C120H218N40O25S4
ANDEQGHILMFSTWY
V
2749.54
10.94
8
0
8
+8
8.60
0.150
96.67
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
250
9.09
4
Residue Composition
number
0
A
4
R
0
N
0
D
4
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
4
P
0
S
0
T
0
W
0
Y
8
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 4 S: 0 T: 0 W: 0 Y: 0 V: 8
Chemical Descriptors
24
C120H218N40O25S4
2749.54
10.94
+8
8.60
0.150
Evidence Records 2 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
0% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational Avoidance of Protease Cleavage Sites and Symmetrical End-Tagging Significantly Enhances the Stability and Therapeutic Potential of Antimicrobial Peptides | J Med Chem | 2020
Evidence 2 Activity

Activity

5% Killing
Toxicity
128 µM
Cytotoxic
5% Killing | 128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Rational Avoidance of Protease Cleavage Sites and Symmetrical End-Tagging Significantly Enhances the Stability and Therapeutic Potential of Antimicrobial Peptides | J Med Chem | 2020