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Peptide record

TPDB10463

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

24 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10463

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FVGPVLKIAAGILPTAICKIYKKC

FASTA

>TPDB10463|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=24
FVGPVLKIAAGILPTAICKIYKKC

Formula C121H204N28O27S2

Absent Amino Acids RNDEQHMSW

Common Amino Acids IK

Mass 2547.24

PI 9.98

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 13

Net Charge +4

Boman Index -0.26

Hydrophobicity 1.067

Aliphatic Index 134.17

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1615

Absorbance 280nm 63.40

Polar Residues 4

number

Amino Acid Distribution

A: 3 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 4 L: 2 K: 4 M: 0 F: 1 P: 2 S: 0 T: 1 W: 0 Y: 1 V: 2

Length

Formula

C121H204N28O27S2

Mass

2547.24

9.98

Net Charge

Boman Index

-0.26

Hydrophobicity

1.067

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.17 µg/mL

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against S. aureus ATCC25923 (MIC 1.17 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 2.34 ug/ml), and C. albicans ATCC

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 µg/mL

Target

Target Organism Staphylococcus aureus ATCC43300

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against S. aureus ATCC25923 (MIC 1.17 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 2.34 ug/ml), and C. albicans ATCC2002 (2.34 ug/ml). Updated 7/2020

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.34 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ctive against S. aureus ATCC25923 (MIC 1.17 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 2.34 ug/ml), and C. albicans ATCC2002 (2.34 ug/ml). Updated 7/2020

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.17 µg/mL

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against S. aureus ATCC25923 (MIC 1.17 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 2.34 ug/ml), and C. albicans ATCC

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 µg/mL

Target

Target Organism Staphylococcus aureus ATCC43300

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against S. aureus ATCC25923 (MIC 1.17 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 2.34 ug/ml), and C. albicans ATCC2002 (2.34 ug/ml). Updated 7/2020

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.34 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ctive against S. aureus ATCC25923 (MIC 1.17 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 2.34 ug/ml), and C. albicans ATCC2002 (2.34 ug/ml). Updated 7/2020

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.17 µg/mL

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against S. aureus ATCC25923 (MIC 1.17 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 2.34 ug/ml), and C. albicans ATCC

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 9.38 µg/mL

Target

Target Organism Staphylococcus aureus ATCC43300

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus ATCC25923 (MIC 1.17 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 2.34 ug/ml), and C. albicans ATCC2002 (2.34 ug/ml). Updated 7/2020

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2.34 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

ctive against S. aureus ATCC25923 (MIC 1.17 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 2.34 ug/ml), and C. albicans ATCC2002 (2.34 ug/ml). Updated 7/2020

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.17 µg/mL

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against S. aureus ATCC25923 (MIC 1.17 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 2.34 ug/ml), and C. albicans ATCC

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 9.38 µg/mL

Target

Target Organism Staphylococcus aureus ATCC43300

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus ATCC25923 (MIC 1.17 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 2.34 ug/ml), and C. albicans ATCC2002 (2.34 ug/ml). Updated 7/2020

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2.34 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

ctive against S. aureus ATCC25923 (MIC 1.17 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 2.34 ug/ml), and C. albicans ATCC2002 (2.34 ug/ml). Updated 7/2020

Evidence 13 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 0.25 %

Hemolysis Raw

[Ref.19778602] It has 18.64 ± 0.25% hemolytic activity at 100 µg/ml against rabbit red blood cells

Target

RBC Target rabbit red blood cells

Source & Reference

Database Source Hemolytik APD_complete PD_Hemolysis

Source DRAMP4

Reference

Genomics. 2010 Jan 95(1):66-71.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 14 Activity

Activity

Activity Endpoint 19% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

19% Hemolysis | 100 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010

Evidence 15 Activity

Activity

Activity Endpoint (45.99±0.36)% Degranulation

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

(45.99±0.36)% Degranulation | 50 | µg/mL | target cell: Rat mast cells

Target

Target Cell Rat mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010

Evidence 16 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.19778602] It has 18.64 ± 0.25% hemolytic activity at 100 µg/ml against rabbit red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Genomics. 2010 Jan 95(1):66-71.

Evidence 17 Hemolysis

Activity

Activity Measurement 0.25 %

Activity Endpoint % Hemolysis

Hemolysis Raw

[Ref.19778602] It has 18.64 ± 0.25% hemolytic activity at 100 µg/ml against rabbit red blood cells

Detail Source Activity Hemolysis

Target

RBC Target rabbit red blood cells

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Reference

Genomics. 2010 Jan 95(1):66-71.

Source DRAMP4

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.