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Peptide record

TPDB10462

Antibacterial Antifungal Hemolysis Toxicity standard

24 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10462

Activity

Antibacterial Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLSTLLNVASKVVPTLFCKITKKC

FASTA

>TPDB10462|Antibacterial;Antifungal;Hemolysis;Toxicity|length=24
FLSTLLNVASKVVPTLFCKITKKC

Formula C123H209N29O31S2

Absent Amino Acids RDEQGHMWY

Common Amino Acids LK

Mass 2654.31

PI 10.17

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +4

Boman Index 0.26

Hydrophobicity 0.846

Aliphatic Index 121.67

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 4.71

Polar Residues 8

number

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 4 K: 4 M: 0 F: 2 P: 1 S: 2 T: 3 W: 0 Y: 0 V: 3

Length

Formula

C123H209N29O31S2

Mass

2654.31

10.17

Net Charge

Boman Index

0.26

Hydrophobicity

0.846

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9 µM

Target

Target Organism Enterococcus faecalis 981

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

ive bacteria: R. rhodochrous X15 (IS) (MIC 2.3 uM), B. licheniformis X39 (IS) (MIC 9 uM), E. faecalis 981 (MIC 9 uM), S. carnosus KHS (IS)(MIC 9 uM), S. aureus ATCC 25923(MIC 9 uM), E.coli ATCC 25922 (MIC 1

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

niformis X39 (IS) (MIC 9 uM), E. faecalis 981 (MIC 9 uM), S. carnosus KHS (IS)(MIC 9 uM), S. aureus ATCC 25923(MIC 9 uM), E.coli ATCC 25922 (MIC 150 uM), P.aeruginosa CGMCC 1.50 (MIC >150 uM), P. aeruginosa 110

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 150 µM

Target

Target Organism E.coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

faecalis 981 (MIC 9 uM), S. carnosus KHS (IS)(MIC 9 uM), S. aureus ATCC 25923(MIC 9 uM), E.coli ATCC 25922 (MIC 150 uM), P.aeruginosa CGMCC 1.50 (MIC >150 uM), P. aeruginosa 11053 (IS)(MIC 75 uM), K.pneumoniae

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 150 µM

Target

Target Organism C.albicans ATCC 10231

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

040724 (IS)(MIC >150 uM), P. faecalis X29 (IS)(MIC 9 uM), S. rubidaea X01 (IS)(MIC 9 uM), C.albicans ATCC 10231 (MIC 150 uM), Slime mold 090223 (IS) (MIC 9 uM). IS: Isolated strain.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9 µM

Target

Target Organism Enterococcus faecalis 981

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 150 µM

Target

Target Organism E.coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 150 µM

Target

Target Organism C.albicans ATCC 10231

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

040724 (IS)(MIC >150 uM), P. faecalis X29 (IS)(MIC 9 uM), S. rubidaea X01 (IS)(MIC 9 uM), C.albicans ATCC 10231 (MIC 150 uM), Slime mold 090223 (IS) (MIC 9 uM). IS: Isolated strain.

Evidence 9 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 37.5 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 37.5 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis | Peptides | 2012

Evidence 10 Hemolysis

Source & Reference

source APD_complete APD_hemolytic HemoPI PD_Hemolysis

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.