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Peptide record

TPDB10462

Antibacterial Antifungal Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10462
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLSTLLNVASKVVPTLFCKITKKC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C123H209N29O31S2
RDEQGHMWY
LK
2654.31
10.17
4
0
11
+4
-0.15
0.846
121.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
0.05
8
Residue Composition
number
1
A
0
R
1
N
0
D
2
C
0
E
0
Q
0
G
0
H
1
I
4
L
4
K
0
M
2
F
1
P
2
S
3
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 4 K: 4 M: 0 F: 2 P: 1 S: 2 T: 3 W: 0 Y: 0 V: 3
Chemical Descriptors
24 reviewed residue count
C123H209N29O31S2 sequence-only estimate (linear, free termini)
2654.31 sequence-only estimate (linear, free termini)
10.17 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
-0.15 sequence-only estimate (linear, free termini)
0.846 sequence-only estimate (linear, free termini)
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
9 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
ive bacteria: R. rhodochrous X15 (IS) (MIC 2.3 uM), B. licheniformis X39 (IS) (MIC 9 uM), E. faecalis 981 (MIC 9 uM), S. carnosus KHS (IS)(MIC 9 uM), S. aureus ATCC 25923(MIC 9 uM), E.coli ATCC 25922 (MIC 1
Evidence 2 Activity

Activity

MIC
Antibacterial
9 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

niformis X39 (IS) (MIC 9 uM), E. faecalis 981 (MIC 9 uM), S. carnosus KHS (IS)(MIC 9 uM), S. aureus ATCC 25923(MIC 9 uM), E.coli ATCC 25922 (MIC 150 uM), P.aeruginosa CGMCC 1.50 (MIC >150 uM), P. aeruginosa 110
Evidence 3 Activity

Activity

MIC
Antibacterial
150 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

faecalis 981 (MIC 9 uM), S. carnosus KHS (IS)(MIC 9 uM), S. aureus ATCC 25923(MIC 9 uM), E.coli ATCC 25922 (MIC 150 uM), P.aeruginosa CGMCC 1.50 (MIC >150 uM), P. aeruginosa 11053 (IS)(MIC 75 uM), K.pneumoniae
Evidence 4 Activity

Activity

MIC
Antibacterial
150 µM

Target

C.albicans ATCC 10231

Source & Reference

dbAMP DRAMP

Other

040724 (IS)(MIC >150 uM), P. faecalis X29 (IS)(MIC 9 uM), S. rubidaea X01 (IS)(MIC 9 uM), C.albicans ATCC 10231 (MIC 150 uM), Slime mold 090223 (IS) (MIC 9 uM). IS: Isolated strain.
Evidence 5 Activity

Activity

MIC
Antifungal
9 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
ive bacteria: R. rhodochrous X15 (IS) (MIC 2.3 uM), B. licheniformis X39 (IS) (MIC 9 uM), E. faecalis 981 (MIC 9 uM), S. carnosus KHS (IS)(MIC 9 uM), S. aureus ATCC 25923(MIC 9 uM), E.coli ATCC 25922 (MIC 1
Evidence 6 Activity

Activity

MIC
Antifungal
9 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

niformis X39 (IS) (MIC 9 uM), E. faecalis 981 (MIC 9 uM), S. carnosus KHS (IS)(MIC 9 uM), S. aureus ATCC 25923(MIC 9 uM), E.coli ATCC 25922 (MIC 150 uM), P.aeruginosa CGMCC 1.50 (MIC >150 uM), P. aeruginosa 110
Evidence 7 Activity

Activity

MIC
Antifungal
150 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

faecalis 981 (MIC 9 uM), S. carnosus KHS (IS)(MIC 9 uM), S. aureus ATCC 25923(MIC 9 uM), E.coli ATCC 25922 (MIC 150 uM), P.aeruginosa CGMCC 1.50 (MIC >150 uM), P. aeruginosa 11053 (IS)(MIC 75 uM), K.pneumoniae
Evidence 8 Activity

Activity

MIC
Antifungal
150 µM

Target

C.albicans ATCC 10231

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

040724 (IS)(MIC >150 uM), P. faecalis X29 (IS)(MIC 9 uM), S. rubidaea X01 (IS)(MIC 9 uM), C.albicans ATCC 10231 (MIC 150 uM), Slime mold 090223 (IS) (MIC 9 uM). IS: Isolated strain.
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
37.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 37.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis | Peptides | 2012
Evidence 10 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.