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Peptide record

TPDB10460

Antibacterial Antifungal Hemolysis Toxicity standard

24 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10460

Activity

Antibacterial Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLPMLAGLAANFLPKIVCKITKKC

FASTA

>TPDB10460|Antibacterial;Antifungal;Hemolysis;Toxicity|length=24
FLPMLAGLAANFLPKIVCKITKKC

Formula C123H207N29O27S3

Absent Amino Acids RDEQHSWY

Common Amino Acids LK

Mass 2620.35

PI 10.17

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 13

Net Charge +4

Boman Index -0.84

Hydrophobicity 0.954

Aliphatic Index 122.08

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 4.77

Polar Residues 4

number

Amino Acid Distribution

A: 3 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 4 K: 4 M: 1 F: 2 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 1

Length

Formula

C123H207N29O27S3

Mass

2620.35

10.17

Net Charge

Boman Index

-0.84

Hydrophobicity

0.954

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9 µM

Target

Target Organism Enterococcus faecalis 981

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

e bacteria: R. rhodochrous X15 (IS) (MIC 0.6 uM), B. licheniformis X39 (IS) (MIC 2.3 uM), E. faecalis 981 (MIC 9 uM), S. carnosus KHS (IS)(MIC 1.2 uM), S. aureus ATCC 25923(MIC 9 uM), E. coli ATCC 25922 (MI

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

rmis X39 (IS) (MIC 2.3 uM), E. faecalis 981 (MIC 9 uM), S. carnosus KHS (IS)(MIC 1.2 uM), S. aureus ATCC 25923(MIC 9 uM), E. coli ATCC 25922 (MIC 75 uM), P. aeruginosa CGMCC 1.50 (MIC 75 uM), P. aeruginosa 1105

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

aecalis 981 (MIC 9 uM), S. carnosus KHS (IS)(MIC 1.2 uM), S. aureus ATCC 25923(MIC 9 uM), E. coli ATCC 25922 (MIC 75 uM), P. aeruginosa CGMCC 1.50 (MIC 75 uM), P. aeruginosa 11053 (IS)(MIC 75 uM), K.pneumoniae

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 37.5 µM

Target

Target Organism Candida albicans ATCC 10231

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

40724 (IS)(MIC 150 uM), P. faecalis X29 (IS)(MIC 9 uM), S. rubidaea X01 (IS)(MIC 4.6 uM), C. albicans ATCC 10231 (MIC 37.5 uM), Slime mold 090223 (IS) (MIC 4.5 uM). IS: Isolated strain.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9 µM

Target

Target Organism Enterococcus faecalis 981

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 37.5 µM

Target

Target Organism Candida albicans ATCC 10231

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

40724 (IS)(MIC 150 uM), P. faecalis X29 (IS)(MIC 9 uM), S. rubidaea X01 (IS)(MIC 4.6 uM), C. albicans ATCC 10231 (MIC 37.5 uM), Slime mold 090223 (IS) (MIC 4.5 uM). IS: Isolated strain.

Evidence 9 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 19 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 19 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis | Peptides | 2012

Evidence 10 Hemolysis

Source & Reference

source APD_complete APD_hemolytic HemoPI PD_Hemolysis

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.