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Peptide record

TPDB10456

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10456
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
DSMGAVKLAKLLIDKMKCEVTKAC
Physicochemical Analysis
C111H199N29O33S4
RNQHFPWY
K
2596.22
9.02
5
3
11
+2
6.41
0.275
101.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
125
4.81
4
Residue Composition
number
3
A
0
R
0
N
2
D
2
C
1
E
0
Q
1
G
0
H
1
I
3
L
5
K
2
M
0
F
0
P
1
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 2 C: 2 E: 1 Q: 0 G: 1 H: 0 I: 1 L: 3 K: 5 M: 2 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
24
C111H199N29O33S4
2596.22
9.02
+2
6.41
0.275
Evidence Records 41 records
Evidence 1 Activity

Activity

MIC
Antibacterial
17 µM

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ S. aureus ATCC25923 (MIC 17 uM), E. faecalis ATCC29212 (MIC 60 uM), S. aureus IS 10# (MIC 40 uM), S.aureus IS 37# (MIC >2
Evidence 2 Activity

Activity

MIC
Antibacterial
60 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ S. aureus ATCC25923 (MIC 17 uM), E. faecalis ATCC29212 (MIC 60 uM), S. aureus IS 10# (MIC 40 uM), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25922
Evidence 3 Activity

Activity

MIC
Antibacterial
10 µM

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP DRAMP

Other

C29212 (MIC 60 uM), S. aureus IS 10# (MIC 40 uM), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25922 (MIC 10 uM), E. coli IS 37# (MIC 60 uM), E.coli IS 117# or 218# (MIC >200 ug/ml), E. cloacae ATCC1304
Evidence 4 Activity

Activity

MIC
Antibacterial
40 µM

Target

Enterobacter cloacae ATCC13047

Source & Reference

dbAMP DRAMP

Other

CC25922 (MIC 10 uM), E. coli IS 37# (MIC 60 uM), E.coli IS 117# or 218# (MIC >200 ug/ml), E. cloacae ATCC13047 (MIC 40 uM), K. pneumonia ATCC700603 (MIC 15 uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa
Evidence 5 Activity

Activity

MIC
Antibacterial
15 µM

Target

K. pneumonia ATCC700603

Source & Reference

dbAMP DRAMP

Other

# (MIC 60 uM), E.coli IS 117# or 218# (MIC >200 ug/ml), E. cloacae ATCC13047 (MIC 40 uM), K. pneumonia ATCC700603 (MIC 15 uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa ATCC27853 or IS 350# (MIC 23 uM), B.
Evidence 6 Activity

Activity

MIC
Antibacterial
17 µM

Target

B. pyocyaneus CMCCB1010

Source & Reference

dbAMP DRAMP

Other

(MIC >200 ug/ml), E. cloacae ATCC13047 (MIC 40 uM), K. pneumonia ATCC700603 (MIC 15 uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa ATCC27853 or IS 350# (MIC 23 uM), B. dysenteriae (MIC 40 uM), K. pneumonia
Evidence 7 Activity

Activity

MIC
Antibacterial
40 µM

Target

B. dysenteriae

Source & Reference

dbAMP DRAMP

Other

uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa ATCC27853 or IS 350# (MIC 23 uM), B. dysenteriae (MIC 40 uM), K. pneumonia IS 59# (MIC 30 uM), fungi C. albicans ATCC2002 (MIC 60 uM), C.albicans ATCC
Evidence 8 Activity

Activity

MIC
Antibacterial
60 µM

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP

Other

r IS 350# (MIC 23 uM), B. dysenteriae (MIC 40 uM), K. pneumonia IS 59# (MIC 30 uM), fungi C. albicans ATCC2002 (MIC 60 uM), C.albicans ATCC2002 (MIC >200 ug/ml). Note that the activity of the synthetic version is
Evidence 9 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

C.albicans ATCC2002

Source & Reference

dbAMP DRAMP

Other

iae (MIC 40 uM), K. pneumonia IS 59# (MIC 30 uM), fungi C. albicans ATCC2002 (MIC 60 uM), C.albicans ATCC2002 (MIC >200 ug/ml). Note that the activity of the synthetic version is less than that of the isolated one, p
Evidence 10 Activity

Activity

MIC
Antifungal
17 µM

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ S. aureus ATCC25923 (MIC 17 uM), E. faecalis ATCC29212 (MIC 60 uM), S. aureus IS 10# (MIC 40 uM), S.aureus IS 37# (MIC >2
Evidence 11 Activity

Activity

MIC
Antifungal
60 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC25923 (MIC 17 uM), E. faecalis ATCC29212 (MIC 60 uM), S. aureus IS 10# (MIC 40 uM), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25922
Evidence 12 Activity

Activity

MIC
Antifungal
10 µM

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C29212 (MIC 60 uM), S. aureus IS 10# (MIC 40 uM), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25922 (MIC 10 uM), E. coli IS 37# (MIC 60 uM), E.coli IS 117# or 218# (MIC >200 ug/ml), E. cloacae ATCC1304
Evidence 13 Activity

Activity

MIC
Antifungal
40 µM

Target

Enterobacter cloacae ATCC13047

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

CC25922 (MIC 10 uM), E. coli IS 37# (MIC 60 uM), E.coli IS 117# or 218# (MIC >200 ug/ml), E. cloacae ATCC13047 (MIC 40 uM), K. pneumonia ATCC700603 (MIC 15 uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa
Evidence 14 Activity

Activity

MIC
Antifungal
15 µM

Target

K. pneumonia ATCC700603

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

# (MIC 60 uM), E.coli IS 117# or 218# (MIC >200 ug/ml), E. cloacae ATCC13047 (MIC 40 uM), K. pneumonia ATCC700603 (MIC 15 uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa ATCC27853 or IS 350# (MIC 23 uM), B.
Evidence 15 Activity

Activity

MIC
Antifungal
17 µM

Target

B. pyocyaneus CMCCB1010

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC >200 ug/ml), E. cloacae ATCC13047 (MIC 40 uM), K. pneumonia ATCC700603 (MIC 15 uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa ATCC27853 or IS 350# (MIC 23 uM), B. dysenteriae (MIC 40 uM), K. pneumonia
Evidence 16 Activity

Activity

MIC
Antifungal
40 µM

Target

B. dysenteriae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa ATCC27853 or IS 350# (MIC 23 uM), B. dysenteriae (MIC 40 uM), K. pneumonia IS 59# (MIC 30 uM), fungi C. albicans ATCC2002 (MIC 60 uM), C.albicans ATCC
Evidence 17 Activity

Activity

MIC
Antifungal
60 µM

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

r IS 350# (MIC 23 uM), B. dysenteriae (MIC 40 uM), K. pneumonia IS 59# (MIC 30 uM), fungi C. albicans ATCC2002 (MIC 60 uM), C.albicans ATCC2002 (MIC >200 ug/ml). Note that the activity of the synthetic version is
Evidence 18 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

C.albicans ATCC2002

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

iae (MIC 40 uM), K. pneumonia IS 59# (MIC 30 uM), fungi C. albicans ATCC2002 (MIC 60 uM), C.albicans ATCC2002 (MIC >200 ug/ml). Note that the activity of the synthetic version is less than that of the isolated one, p
Evidence 19 Activity

Activity

MIC
Antiparasitic
17 µM

Target

Staphylococcus aureus ATCC25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram+ S. aureus ATCC25923 (MIC 17 uM), E. faecalis ATCC29212 (MIC 60 uM), S. aureus IS 10# (MIC 40 uM), S.aureus IS 37# (MIC >2
Evidence 20 Activity

Activity

MIC
Antiparasitic
60 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

DRAMP

Other

Active against Gram+ S. aureus ATCC25923 (MIC 17 uM), E. faecalis ATCC29212 (MIC 60 uM), S. aureus IS 10# (MIC 40 uM), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25922
Evidence 21 Activity

Activity

MIC
Antiparasitic
10 µM

Target

Escherichia coli ATCC25922

Source & Reference

DRAMP

Other

C29212 (MIC 60 uM), S. aureus IS 10# (MIC 40 uM), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25922 (MIC 10 uM), E. coli IS 37# (MIC 60 uM), E.coli IS 117# or 218# (MIC >200 ug/ml), E. cloacae ATCC1304
Evidence 22 Activity

Activity

MIC
Antiparasitic
40 µM

Target

Enterobacter cloacae ATCC13047

Source & Reference

DRAMP

Other

CC25922 (MIC 10 uM), E. coli IS 37# (MIC 60 uM), E.coli IS 117# or 218# (MIC >200 ug/ml), E. cloacae ATCC13047 (MIC 40 uM), K. pneumonia ATCC700603 (MIC 15 uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa
Evidence 23 Activity

Activity

MIC
Antiparasitic
15 µM

Target

K. pneumonia ATCC700603

Source & Reference

DRAMP

Other

# (MIC 60 uM), E.coli IS 117# or 218# (MIC >200 ug/ml), E. cloacae ATCC13047 (MIC 40 uM), K. pneumonia ATCC700603 (MIC 15 uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa ATCC27853 or IS 350# (MIC 23 uM), B.
Evidence 24 Activity

Activity

MIC
Antiparasitic
17 µM

Target

B. pyocyaneus CMCCB1010

Source & Reference

DRAMP

Other

(MIC >200 ug/ml), E. cloacae ATCC13047 (MIC 40 uM), K. pneumonia ATCC700603 (MIC 15 uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa ATCC27853 or IS 350# (MIC 23 uM), B. dysenteriae (MIC 40 uM), K. pneumonia
Evidence 25 Activity

Activity

MIC
Antiparasitic
40 µM

Target

B. dysenteriae

Source & Reference

DRAMP

Other

uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa ATCC27853 or IS 350# (MIC 23 uM), B. dysenteriae (MIC 40 uM), K. pneumonia IS 59# (MIC 30 uM), fungi C. albicans ATCC2002 (MIC 60 uM), C.albicans ATCC
Evidence 26 Activity

Activity

MIC
Antiparasitic
60 µM

Target

Candida albicans ATCC2002

Source & Reference

DRAMP

Other

r IS 350# (MIC 23 uM), B. dysenteriae (MIC 40 uM), K. pneumonia IS 59# (MIC 30 uM), fungi C. albicans ATCC2002 (MIC 60 uM), C.albicans ATCC2002 (MIC >200 ug/ml). Note that the activity of the synthetic version is
Evidence 27 Activity

Activity

MIC
Antiparasitic
>200 µg/mL

Target

C.albicans ATCC2002

Source & Reference

DRAMP

Other

iae (MIC 40 uM), K. pneumonia IS 59# (MIC 30 uM), fungi C. albicans ATCC2002 (MIC 60 uM), C.albicans ATCC2002 (MIC >200 ug/ml). Note that the activity of the synthetic version is less than that of the isolated one, p
Evidence 28 Activity

Activity

MIC
Antiviral
17 µM

Target

Staphylococcus aureus ATCC25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against Gram+ S. aureus ATCC25923 (MIC 17 uM), E. faecalis ATCC29212 (MIC 60 uM), S. aureus IS 10# (MIC 40 uM), S.aureus IS 37# (MIC >2
Evidence 29 Activity

Activity

MIC
Antiviral
60 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

DRAMP

Other

Active against Gram+ S. aureus ATCC25923 (MIC 17 uM), E. faecalis ATCC29212 (MIC 60 uM), S. aureus IS 10# (MIC 40 uM), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25922
Evidence 30 Activity

Activity

MIC
Antiviral
10 µM

Target

Escherichia coli ATCC25922

Source & Reference

DRAMP

Other

C29212 (MIC 60 uM), S. aureus IS 10# (MIC 40 uM), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25922 (MIC 10 uM), E. coli IS 37# (MIC 60 uM), E.coli IS 117# or 218# (MIC >200 ug/ml), E. cloacae ATCC1304
Evidence 31 Activity

Activity

MIC
Antiviral
40 µM

Target

Enterobacter cloacae ATCC13047

Source & Reference

DRAMP

Other

CC25922 (MIC 10 uM), E. coli IS 37# (MIC 60 uM), E.coli IS 117# or 218# (MIC >200 ug/ml), E. cloacae ATCC13047 (MIC 40 uM), K. pneumonia ATCC700603 (MIC 15 uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa
Evidence 32 Activity

Activity

MIC
Antiviral
15 µM

Target

K. pneumonia ATCC700603

Source & Reference

DRAMP

Other

# (MIC 60 uM), E.coli IS 117# or 218# (MIC >200 ug/ml), E. cloacae ATCC13047 (MIC 40 uM), K. pneumonia ATCC700603 (MIC 15 uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa ATCC27853 or IS 350# (MIC 23 uM), B.
Evidence 33 Activity

Activity

MIC
Antiviral
17 µM

Target

B. pyocyaneus CMCCB1010

Source & Reference

DRAMP

Other

(MIC >200 ug/ml), E. cloacae ATCC13047 (MIC 40 uM), K. pneumonia ATCC700603 (MIC 15 uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa ATCC27853 or IS 350# (MIC 23 uM), B. dysenteriae (MIC 40 uM), K. pneumonia
Evidence 34 Activity

Activity

MIC
Antiviral
40 µM

Target

B. dysenteriae

Source & Reference

DRAMP

Other

uM), B. pyocyaneus CMCCB1010 (MIC 17 uM), P. aeruginosa ATCC27853 or IS 350# (MIC 23 uM), B. dysenteriae (MIC 40 uM), K. pneumonia IS 59# (MIC 30 uM), fungi C. albicans ATCC2002 (MIC 60 uM), C.albicans ATCC
Evidence 35 Activity

Activity

MIC
Antiviral
60 µM

Target

Candida albicans ATCC2002

Source & Reference

DRAMP

Other

r IS 350# (MIC 23 uM), B. dysenteriae (MIC 40 uM), K. pneumonia IS 59# (MIC 30 uM), fungi C. albicans ATCC2002 (MIC 60 uM), C.albicans ATCC2002 (MIC >200 ug/ml). Note that the activity of the synthetic version is
Evidence 36 Activity

Activity

MIC
Antiviral
>200 µg/mL

Target

C.albicans ATCC2002

Source & Reference

DRAMP

Other

iae (MIC 40 uM), K. pneumonia IS 59# (MIC 30 uM), fungi C. albicans ATCC2002 (MIC 60 uM), C.albicans ATCC2002 (MIC >200 ug/ml). Note that the activity of the synthetic version is less than that of the isolated one, p
Evidence 37 Activity

Activity

IC50
Hemolysis
150 µM
[Ref.21816202] IC50=150 µM against washed human erythrocytes

Target

washed human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochimie. 2012 Feb 94(2):328-334.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 38 Activity

Activity

50% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
50% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis. | Biochimie | 2012
Evidence 39 Activity

Activity

50% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
50% Hemolysis | 150 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis. | Biochimie | 2012
Evidence 40 Activity

Activity

IC50
Toxicity
150 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.21816202] IC50=150 µM against washed human erythrocytes | Cytotoxicity: [Ref.21816202] Cytotoxicity: the K562 (IC50=46µM)and HT29 mammalian cell lines(IC50=40µM).

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochimie. 2012 Feb 94(2):328-334.
Evidence 41 Hemolysis

Activity

150 µM
IC50
[Ref.21816202] IC50=150 µM against washed human erythrocytes
Hemolysis

Target

washed human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Biochimie. 2012 Feb 94(2):328-334.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.