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Peptide record

TPDB10454

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10454
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept AI4AVP dbAMP 3.0 DRAVP 2.0 APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLRSKIWLWVLLMIWQESNKFKKM
Physicochemical Analysis
C145H228N36O31S2
ADCHPTY
LK
3035.75
10.98
5
1
13
+4
-1.87
-0.013
109.58
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16500
543.52
4
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
1
E
1
Q
1
G
0
H
2
I
4
L
4
K
2
M
1
F
0
P
2
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 2 L: 4 K: 4 M: 2 F: 1 P: 0 S: 2 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
24
C145H228N36O31S2
3035.75
10.98
+4
-1.87
-0.013
Evidence Records 7 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 31.6 uM), SARS-CoV-2 ( de Amaral M, Ienes-Lima J., 2022 ). Also, this peptide can form amyloid-like structure (Amyloid AMPs) ( Caillon et al., 2013 Landreh et al., 2014 ). Chemotactic: Drs S9 can induce the migration of immune cells such as neutrophils, T lymphocytes and monocytes.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 31.6 uM), SARS-CoV-2 ( de Amaral M, Ienes-Lima J., 2022 ). Also, this peptide can form amyloid-like structure (Amyloid AMPs) ( Caillon et al., 2013 Landreh et al., 2014 ). Chemotactic: Drs S9 can induce the migration of immune cells such as neutrophils, T lymphocytes and monocytes.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 31.6 uM), SARS-CoV-2 ( de Amaral M, Ienes-Lima J., 2022 ). Also, this peptide can form amyloid-like structure (Amyloid AMPs) ( Caillon et al., 2013 Landreh et al., 2014 ). Chemotactic: Drs S9 can induce the migration of immune cells such as neutrophils, T lymphocytes and monocytes.
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 31.6 uM), SARS-CoV-2 ( de Amaral M, Ienes-Lima J., 2022 ). Also, this peptide can form amyloid-like structure (Amyloid AMPs) ( Caillon et al., 2013 Landreh et al., 2014 ). Chemotactic: Drs S9 can induce the migration of immune cells such as neutrophils, T lymphocytes and monocytes.
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
175 µM
Hemolytic Cytotoxic
50% Hemolysis | 175 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Dermaseptin S9, an alpha-helical antimicrobial peptide with a hydrophobic core and cationic termini. | Biochemistry | 2006
Evidence 6 Activity

Activity

50% Cell death
Toxicity
>32.9 µM
Cytotoxic
50% Cell death | >32.9 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Antimicrob Agents Chemother | 2010
Evidence 7 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.