TPDB

3D PDB MODEL

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TPDB ID TPDB10452

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLPVLTGLTPSIVPKLVCLLTKKC

FASTA

>TPDB10452|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=24
FLPVLTGLTPSIVPKLVCLLTKKC

Formula C122H211N27O29S2

Absent Amino Acids ARNDEQHMWY

Common Amino Acids L

Mass 2584.30

PI 9.80

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +3

Boman Index -0.19

Hydrophobicity 1.162

Aliphatic Index 150.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 4.84

Polar Residues 6

number

0

A

0

R

0

N

0

D

2

C

0

E

0

Q

1

G

0

H

1

I

6

L

3

K

0

M

1

F

3

P

1

S

3

T

0

W

0

Y

3

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 6 K: 3 M: 0 F: 1 P: 3 S: 1 T: 3 W: 0 Y: 0 V: 3

Length

24

Formula

C122H211N27O29S2

Mass

2584.30

PI

9.80

Net Charge

+3

Boman Index

-0.19

Hydrophobicity

1.162

Evidence 1 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Hemolysis

Activity Measurement 7 µM

Hemolysis Raw

[Ref.15003829] HC50=7µM against human erythrocytes.##[Ref.21295070] LC50= 150µM against human erythrocytes.

Target

RBC Target human erythrocytes

Source & Reference

Database Source Hemolytik APD_complete PD_Hemolysis

Source DRAMP4

Reference

Regul Pept. 2004 May 15 118(3):135-141.## Dev Comp Immunol. 2011 Jun 35(6):644-649.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 150 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis. | Dev Comp Immunol | 2011

Evidence 3 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Toxicity

Activity Measurement 7 µM

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.15003829] HC50=7µM against human erythrocytes.##[Ref.21295070] LC50= 150µM against human erythrocytes.

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Regul Pept. 2004 May 15 118(3):135-141.## Dev Comp Immunol. 2011 Jun 35(6):644-649.

Evidence 4 Hemolysis

Activity

Activity Measurement 7 µM

Activity Endpoint HC50

Hemolysis Raw

[Ref.15003829] HC50=7µM against human erythrocytes.##[Ref.21295070] LC50= 150µM against human erythrocytes.

Detail Source Activity Hemolysis

Target

RBC Target human erythrocytes

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Reference

Regul Pept. 2004 May 15 118(3):135-141.## Dev Comp Immunol. 2011 Jun 35(6):644-649.

Source DRAMP4

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.