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Peptide record

TPDB10450

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10450
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPLIASLAANFVPKIFCKITKKC
Physicochemical Analysis
C128H209N29O28S2
RDEQGHMWY
K
2666.37
10.17
4
0
13
+4
-1.37
1.004
122.08
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.69
5
Residue Composition
number
3
A
0
R
1
N
0
D
2
C
0
E
0
Q
0
G
0
H
3
I
3
L
4
K
0
M
3
F
2
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 3 K: 4 M: 0 F: 3 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
24
C128H209N29O28S2
2666.37
10.17
+4
-1.37
1.004
Evidence Records 32 records
Evidence 1 Activity

Activity

MIC
Antibacterial
19 µM

Target

E. faecium

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
1.2 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP

Other

Active against E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC
Evidence 3 Activity

Activity

MIC
Antibacterial
4.8 µM

Target

S. carnosus KHS

Source & Reference

dbAMP DRAMP

Other

Active against E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. fae
Evidence 4 Activity

Activity

MIC
Antibacterial
2.4 um

Target

B. licheniformis X39

Source & Reference

dbAMP DRAMP

Other

st E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S
Evidence 5 Activity

Activity

MIC
Antibacterial
1.2 µM

Target

R. rhodochrous X15

Source & Reference

dbAMP DRAMP

Other

s ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S. mould 090223 and C. albicans AT
Evidence 6 Activity

Activity

MIC
Antibacterial
4.8 µM

Target

P. faecalis X29

Source & Reference

dbAMP DRAMP

Other

.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 1.2-2.4 uM). Updated 7/2021
Evidence 7 Activity

Activity

MIC
Antibacterial
1.2-2.4 µM

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP

Other

5 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 1.2-2.4 uM). Updated 7/2021
Evidence 8 Activity

Activity

MIC
Antifungal
19 µM

Target

E. faecium

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC
Evidence 9 Activity

Activity

MIC
Antifungal
1.2 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC
Evidence 10 Activity

Activity

MIC
Antifungal
4.8 µM

Target

S. carnosus KHS

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. fae
Evidence 11 Activity

Activity

MIC
Antifungal
2.4 um

Target

B. licheniformis X39

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

st E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S
Evidence 12 Activity

Activity

MIC
Antifungal
1.2 µM

Target

R. rhodochrous X15

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

s ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S. mould 090223 and C. albicans AT
Evidence 13 Activity

Activity

MIC
Antifungal
4.8 µM

Target

P. faecalis X29

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 1.2-2.4 uM). Updated 7/2021
Evidence 14 Activity

Activity

MIC
Antifungal
1.2-2.4 µM

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 1.2-2.4 uM). Updated 7/2021
Evidence 15 Activity

Activity

MIC
Antiparasitic
19 µM

Target

E. faecium

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC
Evidence 16 Activity

Activity

MIC
Antiparasitic
1.2 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

DRAMP

Other

Active against E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC
Evidence 17 Activity

Activity

MIC
Antiparasitic
4.8 µM

Target

S. carnosus KHS

Source & Reference

DRAMP

Other

Active against E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. fae
Evidence 18 Activity

Activity

MIC
Antiparasitic
2.4 um

Target

B. licheniformis X39

Source & Reference

DRAMP

Other

st E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S
Evidence 19 Activity

Activity

MIC
Antiparasitic
1.2 µM

Target

R. rhodochrous X15

Source & Reference

DRAMP

Other

s ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S. mould 090223 and C. albicans AT
Evidence 20 Activity

Activity

MIC
Antiparasitic
4.8 µM

Target

P. faecalis X29

Source & Reference

DRAMP

Other

.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 1.2-2.4 uM). Updated 7/2021
Evidence 21 Activity

Activity

MIC
Antiparasitic
1.2-2.4 µM

Target

Candida albicans ATCC2002

Source & Reference

DRAMP

Other

5 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 1.2-2.4 uM). Updated 7/2021
Evidence 22 Activity

Activity

MIC
Antiviral
19 µM

Target

E. faecium

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC
Evidence 23 Activity

Activity

MIC
Antiviral
1.2 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

DRAMP

Other

Active against E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC
Evidence 24 Activity

Activity

MIC
Antiviral
4.8 µM

Target

S. carnosus KHS

Source & Reference

DRAMP

Other

Active against E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. fae
Evidence 25 Activity

Activity

MIC
Antiviral
2.4 um

Target

B. licheniformis X39

Source & Reference

DRAMP

Other

st E. faecium (MIC 19 uM), S. aureus ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S
Evidence 26 Activity

Activity

MIC
Antiviral
1.2 µM

Target

R. rhodochrous X15

Source & Reference

DRAMP

Other

s ATCC2592 (MIC 1.2 uM), S. carnosus KHS (MIC 4.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S. mould 090223 and C. albicans AT
Evidence 27 Activity

Activity

MIC
Antiviral
4.8 µM

Target

P. faecalis X29

Source & Reference

DRAMP

Other

.8 uM), B. licheniformis X39 (MIC 2.4 um), R. rhodochrous X15 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 1.2-2.4 uM). Updated 7/2021
Evidence 28 Activity

Activity

MIC
Antiviral
1.2-2.4 µM

Target

Candida albicans ATCC2002

Source & Reference

DRAMP

Other

5 (MIC 1.2 uM) Gram-negative P. faecalis X29 (MIC 4.8 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 1.2-2.4 uM). Updated 7/2021
Evidence 29 Activity

Activity

LC50
Hemolysis
75 µM
[Ref.22450466] LC50=75 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Peptides. 2012 Jun 35(2):285-290.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 30 Activity

Activity

50% Hemolysis
Toxicity
75 µM
Hemolytic Cytotoxic
50% Hemolysis | 75 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis. | Peptides | 2012
Evidence 31 Activity

Activity

LC50
Toxicity
75 µM
Hemolytic
Hemolytic_activity: [Ref.22450466] LC50=75 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2012 Jun 35(2):285-290.
Evidence 32 Hemolysis

Activity

75 µM
LC50
[Ref.22450466] LC50=75 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Peptides. 2012 Jun 35(2):285-290.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.