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Peptide record

TPDB10449

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10449
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLGSLLGLVGKVVPTLFCKISKKC
Physicochemical Analysis
C120H204N28O28S2
ARNDEQHMWY
L
2551.23
10.17
4
0
11
+4
-0.80
1.083
133.75
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.90
5
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
0
E
0
Q
3
G
0
H
1
I
5
L
4
K
0
M
2
F
1
P
2
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 5 K: 4 M: 0 F: 2 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
24
C120H204N28O28S2
2551.23
10.17
+4
-0.80
1.083
Evidence Records 7 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus ATCC2592, R. rhodochrous (Gram-poistive) and P. faecalis X29 (Gram-). Updated 10/16/2012 GW.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus ATCC2592, R. rhodochrous (Gram-poistive) and P. faecalis X29 (Gram-). Updated 10/16/2012 GW.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Active against S. aureus ATCC2592, R. rhodochrous (Gram-poistive) and P. faecalis X29 (Gram-). Updated 10/16/2012 GW.
Evidence 4 Activity

Activity

Hemolysis
[Ref.22100518]LD50=200 µg/ml against rabbit red blood cells

Target

rabbit red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Peptides. 2012 Jan 33(1):27-34.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
200.0 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 200.0 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae). | Peptides | 2012
Evidence 6 Activity

Activity

LD50
Toxicity
200 µg/mL
Hemolytic
Hemolytic_activity: [Ref.22100518]LD50=200 µg/ml against rabbit red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2012 Jan 33(1):27-34.
Evidence 7 Hemolysis

Activity

[Ref.22100518]LD50=200 µg/ml against rabbit red blood cells
Hemolysis

Target

rabbit red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
Peptides. 2012 Jan 33(1):27-34.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.