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Peptide record

TPDB10447

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10447
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FIGPVLKIAAGILPTAICKIFKKC
Physicochemical Analysis
C122H206N28O26S2
RNDEQHMSWY
I
2545.27
10.17
4
0
13
+4
-0.83
1.250
138.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.91
3
Residue Composition
number
3
A
0
R
0
N
0
D
2
C
0
E
0
Q
2
G
0
H
5
I
2
L
4
K
0
M
2
F
2
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 5 L: 2 K: 4 M: 0 F: 2 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
24
C122H206N28O26S2
2545.27
10.17
+4
-0.83
1.250
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.34 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC25923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
9.38 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC25923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC 18.75 ug/ml), and C. albicans ATCC2002
Evidence 3 Activity

Activity

MIC
Antibacterial
4.69 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

ctive against S. aureus ATCC25923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC 18.75 ug/ml), and C. albicans ATCC2002 (4.69 ug/ml). 50% hemolysis a
Evidence 4 Activity

Activity

MIC
Antibacterial
18.75 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

dbAMP DRAMP

Other

923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC 18.75 ug/ml), and C. albicans ATCC2002 (4.69 ug/ml). 50% hemolysis at 100 uM. Updated 7/2020
Evidence 5 Activity

Activity

MIC
Antifungal
2.34 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus ATCC25923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC
Evidence 6 Activity

Activity

MIC
Antifungal
9.38 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC25923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC 18.75 ug/ml), and C. albicans ATCC2002
Evidence 7 Activity

Activity

MIC
Antifungal
4.69 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ctive against S. aureus ATCC25923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC 18.75 ug/ml), and C. albicans ATCC2002 (4.69 ug/ml). 50% hemolysis a
Evidence 8 Activity

Activity

MIC
Antifungal
18.75 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC 18.75 ug/ml), and C. albicans ATCC2002 (4.69 ug/ml). 50% hemolysis at 100 uM. Updated 7/2020
Evidence 9 Activity

Activity

MIC
Antiparasitic
2.34 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against S. aureus ATCC25923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC
Evidence 10 Activity

Activity

MIC
Antiparasitic
9.38 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC 18.75 ug/ml), and C. albicans ATCC2002
Evidence 11 Activity

Activity

MIC
Antiparasitic
4.69 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

ctive against S. aureus ATCC25923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC 18.75 ug/ml), and C. albicans ATCC2002 (4.69 ug/ml). 50% hemolysis a
Evidence 12 Activity

Activity

MIC
Antiparasitic
18.75 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

DRAMP

Other

923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC 18.75 ug/ml), and C. albicans ATCC2002 (4.69 ug/ml). 50% hemolysis at 100 uM. Updated 7/2020
Evidence 13 Activity

Activity

MIC
Antiviral
2.34 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against S. aureus ATCC25923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC
Evidence 14 Activity

Activity

MIC
Antiviral
9.38 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC 18.75 ug/ml), and C. albicans ATCC2002
Evidence 15 Activity

Activity

MIC
Antiviral
4.69 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

ctive against S. aureus ATCC25923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC 18.75 ug/ml), and C. albicans ATCC2002 (4.69 ug/ml). 50% hemolysis a
Evidence 16 Activity

Activity

MIC
Antiviral
18.75 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

DRAMP

Other

923 (MIC 2.34 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 4.69 ug/ml), E. coli ML-35P (MIC 18.75 ug/ml), and C. albicans ATCC2002 (4.69 ug/ml). 50% hemolysis at 100 uM. Updated 7/2020
Evidence 17 Activity

Activity

% Hemolysis
Hemolysis
1.49 %
[Ref.19778602] It has 46.13 ± 1.49% hemolytic activity at 100 µg/ml against rabbit red blood cells

Target

rabbit red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Genomics. 2010 Jan 95(1):66-71.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 18 Activity

Activity

46% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
46% Hemolysis | 100 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010
Evidence 19 Activity

Activity

(63.86±10.17)% Degranulation
Toxicity
50 µg/mL
Cytotoxic
(63.86±10.17)% Degranulation | 50 | µg/mL | target cell: Rat mast cells

Target

Rat mast cells

Source & Reference

NA
DBAASP
Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010
Evidence 20 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.19778602] It has 46.13 ± 1.49% hemolytic activity at 100 µg/ml against rabbit red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Genomics. 2010 Jan 95(1):66-71.
Evidence 21 Hemolysis

Activity

1.49 %
% Hemolysis
[Ref.19778602] It has 46.13 ± 1.49% hemolytic activity at 100 µg/ml against rabbit red blood cells
Hemolysis

Target

rabbit red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
Genomics. 2010 Jan 95(1):66-71.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.