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Peptide record

TPDB10435

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10435
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLKDKFKSMGEKLKQYIQTWKAKF
Physicochemical Analysis
C136H216N34O34S1
RNCHPV
K
2903.48
10.48
7
2
9
+5
4.75
-1.017
52.92
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
240.75
5
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
1
E
2
Q
2
G
0
H
1
I
2
L
7
K
1
M
2
F
0
P
1
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 2 G: 2 H: 0 I: 1 L: 2 K: 7 M: 1 F: 2 P: 0 S: 1 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
24
C136H216N34O34S1
2903.48
10.48
+5
4.75
-1.017
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.3-4.5 µM

Target

Escherichia coli DH1

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 2.3-4.5 uM), P-aeruginosa (MIC>35 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.1 uM), yeasts P.
Evidence 2 Activity

Activity

MIC
Antibacterial
0.3-1.1 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

i DH5alpha, E. coli DH1 (MIC 2.3-4.5 uM), P-aeruginosa (MIC>35 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.1 uM), yeasts P. pastoris, S. cerevisiae (MIC 18-36 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
18-36 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

nosa (MIC>35 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.1 uM), yeasts P. pastoris, S. cerevisiae (MIC 18-36 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
2.3-4.5 µM

Target

Escherichia coli DH1

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 2.3-4.5 uM), P-aeruginosa (MIC>35 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.1 uM), yeasts P.
Evidence 5 Activity

Activity

MIC
Antifungal
0.3-1.1 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

i DH5alpha, E. coli DH1 (MIC 2.3-4.5 uM), P-aeruginosa (MIC>35 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.1 uM), yeasts P. pastoris, S. cerevisiae (MIC 18-36 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
18-36 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

nosa (MIC>35 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.1 uM), yeasts P. pastoris, S. cerevisiae (MIC 18-36 uM).
Evidence 7 Activity

Activity

MIC
Antiparasitic
2.3-4.5 µM

Target

Escherichia coli DH1

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 2.3-4.5 uM), P-aeruginosa (MIC>35 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.1 uM), yeasts P.
Evidence 8 Activity

Activity

MIC
Antiparasitic
0.3-1.1 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

i DH5alpha, E. coli DH1 (MIC 2.3-4.5 uM), P-aeruginosa (MIC>35 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.1 uM), yeasts P. pastoris, S. cerevisiae (MIC 18-36 uM).
Evidence 9 Activity

Activity

MIC
Antiparasitic
18-36 µM

Target

S. cerevisiae

Source & Reference

DRAMP

Other

nosa (MIC>35 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.1 uM), yeasts P. pastoris, S. cerevisiae (MIC 18-36 uM).
Evidence 10 Activity

Activity

20% Hemolysis
Toxicity
>120 µM
Hemolytic Cytotoxic
20% Hemolysis | >120 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity. | J Biol Chem | 2006
Evidence 11 Activity

Activity

12% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
12% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Membrane Interactions of Latarcins: Antimicrobial Peptides from Spider Venom | Int J Mol Sci | 2021
Evidence 12 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.16735513]20% hemolytic activity at >120 µM against rabbit erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2006 Jul 28 281(30):20983-209892.