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Peptide record

TPDB10433

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10433
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 dbACP iACP-DRLF Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPLAVSLAANFLPKLFCKITKKC
Physicochemical Analysis
C128H209N29O28S2
RDEQGHMWY
L
2666.37
10.17
4
0
13
+4
-1.87
0.946
122.08
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.69
5
Residue Composition
number
3
A
0
R
1
N
0
D
2
C
0
E
0
Q
0
G
0
H
1
I
5
L
4
K
0
M
3
F
2
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 5 K: 4 M: 0 F: 3 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
24
C128H209N29O28S2
2666.37
10.17
+4
-1.87
0.946
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5.5 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ S. aureus (MIC 5.5 ug/ml), Gram- E. coli, B. dysenteriae (MIC 2.2-6.5 ug/ml), and fungi C. albicans (MIC 7.5 ug/ml)
Evidence 2 Activity

Activity

MIC
Antibacterial
2.2-6.5 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ S. aureus (MIC 5.5 ug/ml), Gram- E. coli, B. dysenteriae (MIC 2.2-6.5 ug/ml), and fungi C. albicans (MIC 7.5 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
7.5 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

+ S. aureus (MIC 5.5 ug/ml), Gram- E. coli, B. dysenteriae (MIC 2.2-6.5 ug/ml), and fungi C. albicans (MIC 7.5 ug/ml).
Evidence 4 Activity

Activity

MIC
Antifungal
5.5 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ S. aureus (MIC 5.5 ug/ml), Gram- E. coli, B. dysenteriae (MIC 2.2-6.5 ug/ml), and fungi C. albicans (MIC 7.5 ug/ml)
Evidence 5 Activity

Activity

MIC
Antifungal
2.2-6.5 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus (MIC 5.5 ug/ml), Gram- E. coli, B. dysenteriae (MIC 2.2-6.5 ug/ml), and fungi C. albicans (MIC 7.5 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
7.5 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

+ S. aureus (MIC 5.5 ug/ml), Gram- E. coli, B. dysenteriae (MIC 2.2-6.5 ug/ml), and fungi C. albicans (MIC 7.5 ug/ml).
Evidence 7 Activity

Activity

MIC
Antiparasitic
5.5 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram+ S. aureus (MIC 5.5 ug/ml), Gram- E. coli, B. dysenteriae (MIC 2.2-6.5 ug/ml), and fungi C. albicans (MIC 7.5 ug/ml)
Evidence 8 Activity

Activity

MIC
Antiparasitic
2.2-6.5 µg/mL

Target

B. dysenteriae

Source & Reference

DRAMP

Other

Active against Gram+ S. aureus (MIC 5.5 ug/ml), Gram- E. coli, B. dysenteriae (MIC 2.2-6.5 ug/ml), and fungi C. albicans (MIC 7.5 ug/ml).
Evidence 9 Activity

Activity

MIC
Antiparasitic
7.5 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

+ S. aureus (MIC 5.5 ug/ml), Gram- E. coli, B. dysenteriae (MIC 2.2-6.5 ug/ml), and fungi C. albicans (MIC 7.5 ug/ml).
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
5 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 5 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis | Peptides | 2006
Evidence 11 Activity

Activity

96% Hemolysis
Toxicity
20 µg/mL
Hemolytic Cytotoxic
96% Hemolysis | 20 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis | Peptides | 2006
Evidence 12 Activity

Activity

17% degranulation
Toxicity
100 µg/mL
Cytotoxic
17% degranulation | 100 | µg/mL | target cell: Rat mast cells

Target

Rat mast cells

Source & Reference

NA
DBAASP
Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis | Peptides | 2006
Evidence 13 Activity

Activity

IC50
Toxicity
58
Cytotoxic
Cytotoxicity: [Ref.17000029]Display cytotoxicity against HepG2(IC50=58 mg/ml).

Source & Reference

NA
DRAMP
Peptides. 2006 Dec 27(12):3085-3091.
Evidence 14 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.