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Peptide record

TPDB10432

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10432
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPIIAGVAAKVLPKLFCAITKKC
Physicochemical Analysis
C122H206N28O26S2
RNDEQHMSWY
AK
2545.27
10.17
4
0
14
+4
-0.88
1.300
138.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.91
3
Residue Composition
number
4
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
3
I
3
L
4
K
0
M
2
F
2
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 3 K: 4 M: 0 F: 2 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
24
C122H206N28O26S2
2545.27
10.17
+4
-0.88
1.300
Evidence Records 19 records
Evidence 1 Activity

Activity

MIC
Antibacterial
10 µM

Target

Escherichia coli ATCC 25726

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC 25726 (MIC 10 uM), K. pneumoniae ATCC 700603 (MIC 40 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), S. aureus A
Evidence 2 Activity

Activity

MIC
Antibacterial
40 µM

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC 25726 (MIC 10 uM), K. pneumoniae ATCC 700603 (MIC 40 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), S. aureus ATCC 25923 (MIC 2.5 uM), and C. albicans
Evidence 3 Activity

Activity

MIC
Antibacterial
20 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC 25726 (MIC 10 uM), K. pneumoniae ATCC 700603 (MIC 40 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), S. aureus ATCC 25923 (MIC 2.5 uM), and C. albicans ATCC 90028 (MIC 2.5 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

(MIC 10 uM), K. pneumoniae ATCC 700603 (MIC 40 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), S. aureus ATCC 25923 (MIC 2.5 uM), and C. albicans ATCC 90028 (MIC 2.5 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP

Other

(MIC 40 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), S. aureus ATCC 25923 (MIC 2.5 uM), and C. albicans ATCC 90028 (MIC 2.5 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
10 µM

Target

Escherichia coli ATCC 25726

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC 25726 (MIC 10 uM), K. pneumoniae ATCC 700603 (MIC 40 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), S. aureus A
Evidence 7 Activity

Activity

MIC
Antifungal
40 µM

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25726 (MIC 10 uM), K. pneumoniae ATCC 700603 (MIC 40 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), S. aureus ATCC 25923 (MIC 2.5 uM), and C. albicans
Evidence 8 Activity

Activity

MIC
Antifungal
20 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25726 (MIC 10 uM), K. pneumoniae ATCC 700603 (MIC 40 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), S. aureus ATCC 25923 (MIC 2.5 uM), and C. albicans ATCC 90028 (MIC 2.5 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
2.5 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 10 uM), K. pneumoniae ATCC 700603 (MIC 40 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), S. aureus ATCC 25923 (MIC 2.5 uM), and C. albicans ATCC 90028 (MIC 2.5 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
2.5 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 40 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), S. aureus ATCC 25923 (MIC 2.5 uM), and C. albicans ATCC 90028 (MIC 2.5 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
10 µM

Target

Escherichia coli ATCC 25726

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli ATCC 25726 (MIC 10 uM), K. pneumoniae ATCC 700603 (MIC 40 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), S. aureus A
Evidence 12 Activity

Activity

MIC
Antiparasitic
40 µM

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

DRAMP

Other

Active against E. coli ATCC 25726 (MIC 10 uM), K. pneumoniae ATCC 700603 (MIC 40 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), S. aureus ATCC 25923 (MIC 2.5 uM), and C. albicans
Evidence 13 Activity

Activity

MIC
Antiparasitic
20 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

Active against E. coli ATCC 25726 (MIC 10 uM), K. pneumoniae ATCC 700603 (MIC 40 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), S. aureus ATCC 25923 (MIC 2.5 uM), and C. albicans ATCC 90028 (MIC 2.5 uM).
Evidence 14 Activity

Activity

MIC
Antiparasitic
2.5 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

DRAMP

Other

(MIC 10 uM), K. pneumoniae ATCC 700603 (MIC 40 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), S. aureus ATCC 25923 (MIC 2.5 uM), and C. albicans ATCC 90028 (MIC 2.5 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
2.5 µM

Target

Candida albicans ATCC 90028

Source & Reference

DRAMP

Other

(MIC 40 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), S. aureus ATCC 25923 (MIC 2.5 uM), and C. albicans ATCC 90028 (MIC 2.5 uM).
Evidence 16 Activity

Activity

LC50
Hemolysis
5 µM
[Ref.21262304] LC50=5 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Mol Evol. 2007 Nov 65(5):605-615.##Peptides. 2011 Apr 32(4):664-669.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 17 Activity

Activity

50% Hemolysis
Toxicity
5 µM
Hemolytic Cytotoxic
50% Hemolysis | 5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona. | Peptides | 2011
Evidence 18 Activity

Activity

LC50
Toxicity
5 µM
Hemolytic
Hemolytic_activity: [Ref.21262304] LC50=5 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
J Mol Evol. 2007 Nov 65(5):605-615.##Peptides. 2011 Apr 32(4):664-669.
Evidence 19 Hemolysis

Activity

5 µM
LC50
[Ref.21262304] LC50=5 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Mol Evol. 2007 Nov 65(5):605-615.##Peptides. 2011 Apr 32(4):664-669.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.