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Peptide record

TPDB10431

Brevinin-1BLa Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10431
Brevinin-1BLa
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPIIAGAAAKVVEKIFCAISKKC
Physicochemical Analysis
C118H198N28O28S2
RNDQHMTWY
A
2521.16
9.72
4
1
14
+3
1.32
1.163
126.25
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.96
3
Residue Composition
number
5
A
0
R
0
N
0
D
2
C
1
E
0
Q
1
G
0
H
4
I
1
L
4
K
0
M
2
F
1
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 5 R: 0 N: 0 D: 0 C: 2 E: 1 Q: 0 G: 1 H: 0 I: 4 L: 1 K: 4 M: 0 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
24
C118H198N28O28S2
2521.16
9.72
+3
1.32
1.163
Free
L
Not Available
Free
Antibacterial
North America, leopard frog, Lithobates blairi
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
100 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 100 uM), S. aureus (6 uM), C. albicans (6 uM), cancer cells HepG2 (LC50 14 uM).
Evidence 2 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2009

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 3 Activity

Activity

MIC
Antifungal
100 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 100 uM), S. aureus (6 uM), C. albicans (6 uM), cancer cells HepG2 (LC50 14 uM).
Evidence 4 Activity

Activity

MIC
Antiparasitic
100 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 100 uM), S. aureus (6 uM), C. albicans (6 uM), cancer cells HepG2 (LC50 14 uM).
Evidence 5 Activity

Activity

MIC
Antiviral
100 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli (MIC 100 uM), S. aureus (6 uM), C. albicans (6 uM), cancer cells HepG2 (LC50 14 uM).
Evidence 6 Activity

Activity

LC50
Hemolysis
13 µM
[Ref.19254736] LC50=13 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Toxicon. 2009 Jun 53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
13 µM
Hemolytic Cytotoxic
50% Hemolysis | 13 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis. | Toxicon | 2009
Evidence 8 Activity

Activity

LC50
Toxicity
13 µM
Hemolytic
Hemolytic_activity: [Ref.19254736] LC50=13 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxicon. 2009 Jun 53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.
Evidence 9 Hemolysis

Activity

13 µM
LC50
[Ref.19254736] LC50=13 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Toxicon. 2009 Jun 53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.