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Peptide record

TPDB10428

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10428
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPILAGLAANILPKVFCSITKKC
Physicochemical Analysis
C121H202N28O28S2
RDEQHMWY
L
2561.23
9.80
3
0
13
+3
-1.78
1.192
138.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.88
5
Residue Composition
number
3
A
0
R
1
N
0
D
2
C
0
E
0
Q
1
G
0
H
3
I
4
L
3
K
0
M
2
F
2
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 4 K: 3 M: 0 F: 2 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
24
C121H202N28O28S2
2561.23
9.80
+3
-1.78
1.192
Evidence Records 24 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 25 uM), P. aeruginosa (25 uM), E. cloacae (25 uM), S. aureus (MIC 3 uM), S. epidermidis (6 uM),
Evidence 2 Activity

Activity

MIC
Antibacterial
3 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 25 uM), P. aeruginosa (25 uM), E. cloacae (25 uM), S. aureus (MIC 3 uM), S. epidermidis (6 uM), E. faecalis (6 uM), Streptococcus Group B (13 uM), C. albicans (M
Evidence 3 Activity

Activity

MIC
Antibacterial
3 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

eus (MIC 3 uM), S. epidermidis (6 uM), E. faecalis (6 uM), Streptococcus Group B (13 uM), C. albicans (MIC 3 uM), K.pneumoniae (MIC >50 uM) and P.mirabilis (MIC >50 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
>50 µM

Target

K.pneumoniae

Source & Reference

dbAMP DRAMP

Other

rmidis (6 uM), E. faecalis (6 uM), Streptococcus Group B (13 uM), C. albicans (MIC 3 uM), K.pneumoniae (MIC >50 uM) and P.mirabilis (MIC >50 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
>50 µM

Target

P.mirabilis

Source & Reference

dbAMP DRAMP

Other

uM), Streptococcus Group B (13 uM), C. albicans (MIC 3 uM), K.pneumoniae (MIC >50 uM) and P.mirabilis (MIC >50 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 25 uM), P. aeruginosa (25 uM), E. cloacae (25 uM), S. aureus (MIC 3 uM), S. epidermidis (6 uM),
Evidence 7 Activity

Activity

MIC
Antifungal
3 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 25 uM), P. aeruginosa (25 uM), E. cloacae (25 uM), S. aureus (MIC 3 uM), S. epidermidis (6 uM), E. faecalis (6 uM), Streptococcus Group B (13 uM), C. albicans (M
Evidence 8 Activity

Activity

MIC
Antifungal
3 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

eus (MIC 3 uM), S. epidermidis (6 uM), E. faecalis (6 uM), Streptococcus Group B (13 uM), C. albicans (MIC 3 uM), K.pneumoniae (MIC >50 uM) and P.mirabilis (MIC >50 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
>50 µM

Target

K.pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

rmidis (6 uM), E. faecalis (6 uM), Streptococcus Group B (13 uM), C. albicans (MIC 3 uM), K.pneumoniae (MIC >50 uM) and P.mirabilis (MIC >50 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
>50 µM

Target

P.mirabilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), Streptococcus Group B (13 uM), C. albicans (MIC 3 uM), K.pneumoniae (MIC >50 uM) and P.mirabilis (MIC >50 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 25 uM), P. aeruginosa (25 uM), E. cloacae (25 uM), S. aureus (MIC 3 uM), S. epidermidis (6 uM),
Evidence 12 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against E. coli (MIC 25 uM), P. aeruginosa (25 uM), E. cloacae (25 uM), S. aureus (MIC 3 uM), S. epidermidis (6 uM), E. faecalis (6 uM), Streptococcus Group B (13 uM), C. albicans (M
Evidence 13 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

eus (MIC 3 uM), S. epidermidis (6 uM), E. faecalis (6 uM), Streptococcus Group B (13 uM), C. albicans (MIC 3 uM), K.pneumoniae (MIC >50 uM) and P.mirabilis (MIC >50 uM).
Evidence 14 Activity

Activity

MIC
Antiparasitic
>50 µM

Target

K.pneumoniae

Source & Reference

DRAMP

Other

rmidis (6 uM), E. faecalis (6 uM), Streptococcus Group B (13 uM), C. albicans (MIC 3 uM), K.pneumoniae (MIC >50 uM) and P.mirabilis (MIC >50 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
>50 µM

Target

P.mirabilis

Source & Reference

DRAMP

Other

uM), Streptococcus Group B (13 uM), C. albicans (MIC 3 uM), K.pneumoniae (MIC >50 uM) and P.mirabilis (MIC >50 uM).
Evidence 16 Activity

Activity

MIC
Antiviral
25 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli (MIC 25 uM), P. aeruginosa (25 uM), E. cloacae (25 uM), S. aureus (MIC 3 uM), S. epidermidis (6 uM),
Evidence 17 Activity

Activity

MIC
Antiviral
3 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against E. coli (MIC 25 uM), P. aeruginosa (25 uM), E. cloacae (25 uM), S. aureus (MIC 3 uM), S. epidermidis (6 uM), E. faecalis (6 uM), Streptococcus Group B (13 uM), C. albicans (M
Evidence 18 Activity

Activity

MIC
Antiviral
3 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

eus (MIC 3 uM), S. epidermidis (6 uM), E. faecalis (6 uM), Streptococcus Group B (13 uM), C. albicans (MIC 3 uM), K.pneumoniae (MIC >50 uM) and P.mirabilis (MIC >50 uM).
Evidence 19 Activity

Activity

MIC
Antiviral
>50 µM

Target

K.pneumoniae

Source & Reference

DRAMP

Other

rmidis (6 uM), E. faecalis (6 uM), Streptococcus Group B (13 uM), C. albicans (MIC 3 uM), K.pneumoniae (MIC >50 uM) and P.mirabilis (MIC >50 uM).
Evidence 20 Activity

Activity

MIC
Antiviral
>50 µM

Target

P.mirabilis

Source & Reference

DRAMP

Other

uM), Streptococcus Group B (13 uM), C. albicans (MIC 3 uM), K.pneumoniae (MIC >50 uM) and P.mirabilis (MIC >50 uM).
Evidence 21 Activity

Activity

HC50
Hemolysis
7 µM
[Ref.15325526] HC50=7 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Dev Comp Immunol. 2005 29(1):83-90.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 22 Activity

Activity

50% Hemolysis
Toxicity
7 µM
Hemolytic Cytotoxic
50% Hemolysis | 7 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora. | Dev Comp Immunol | 2005
Evidence 23 Activity

Activity

HC50
Toxicity
7 µM
Hemolytic
Hemolytic_activity: [Ref.15325526] HC50=7 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Dev Comp Immunol. 2005 29(1):83-90.
Evidence 24 Hemolysis

Activity

7 µM
HC50
[Ref.15325526] HC50=7 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Dev Comp Immunol. 2005 29(1):83-90.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.