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Peptide record

TPDB10423

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10423
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 SATPdb iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLGLLFHGVHHVGKWIHGLIHGHH
Physicochemical Analysis
C133H190N40O25
ARNDCEQMPSTY
H
2749.22
10.10
8
0
11
+2
0.93
0.375
121.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
200.06
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
5
G
7
H
2
I
4
L
1
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 5 H: 7 I: 2 L: 4 K: 1 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
24
C133H190N40O25
2749.22
10.10
+2
0.93
0.375
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
16 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 16 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 2 Activity

Activity

>10% Killing
Toxicity
5 µM
Cytotoxic
>10% Killing | 5 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 3 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.