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Peptide record

TPDB10419

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10419
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPILASLAAKLGPKLFCLVTKKC
Physicochemical Analysis
C123H208N28O27S2
RNDEQHMWY
L
2575.30
10.17
4
0
13
+4
-1.71
1.117
138.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.85
4
Residue Composition
number
3
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
1
I
6
L
4
K
0
M
2
F
2
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 6 K: 4 M: 0 F: 2 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
24
C123H208N28O27S2
2575.30
10.17
+4
-1.71
1.117
Evidence Records 4 records
Evidence 1 Activity

Activity

HC50
Hemolysis
4 µM
[Ref.14531844]HC50=4 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Pept Res. 2003 Nov 62(5):207-213.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
4 µM
Hemolytic Cytotoxic
50% Hemolysis | 4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Isolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii. | J Pept Res | 2003
Evidence 3 Activity

Activity

HC50
Toxicity
4 µM
Hemolytic
Hemolytic_activity: [Ref.14531844]HC50=4 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Res. 2003 Nov 62(5):207-213.
Evidence 4 Hemolysis

Activity

4 µM
HC50
[Ref.14531844]HC50=4 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Pept Res. 2003 Nov 62(5):207-213.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.