Back to search

Peptide record

TPDB10418

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard

24 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10418

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 Antifungipept CAFPdb i2APP AI4AVP dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

LLKELWTKIKGAGKAVLGKIKGLL

FASTA

>TPDB10418|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Toxicity|length=24
LLKELWTKIKGAGKAVLGKIKGLL

Formula C123H217N31O28

Absent Amino Acids RNDCQHMFPSY

Common Amino Acids LK

Mass 2578.27

PI 10.82

Basic Residues 6

Acidic Residues 1

Hydrophobic Residues 12

Net Charge +5

Boman Index 2.04

Hydrophobicity 0.396

Aliphatic Index 150.42

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 213.32

Polar Residues 1

number

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 4 H: 0 I: 2 L: 6 K: 6 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 1

Length

Formula

C123H217N31O28

Mass

2578.27

10.82

Net Charge

Boman Index

2.04

Hydrophobicity

0.396

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2-85 µM

Target

Target Organism Staphylococcus aureus CIP 677 MRSA

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

CIP A22. MIC measurement: active against L. lactis ssp. cremoris I 116 (MIC < 0.125 uM), S. aureus CIP 677 MRSA (MIC 2-85 uM), Gram- E. coli L2, K. pneumoniae CIP 8291 (MIC 2-4 uM), P. putida LMA (16-32 uM), and S.

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2-4 µM

Target

Target Organism Klebsiella pneumoniae CIP 8291

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

cremoris I 116 (MIC < 0.125 uM), S. aureus CIP 677 MRSA (MIC 2-85 uM), Gram- E. coli L2, K. pneumoniae CIP 8291 (MIC 2-4 uM), P. putida LMA (16-32 uM), and S. enterica CIP 813 (MIC 8-16 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8-16 µM

Target

Target Organism S. enterica CIP 813

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

uM), Gram- E. coli L2, K. pneumoniae CIP 8291 (MIC 2-4 uM), P. putida LMA (16-32 uM), and S. enterica CIP 813 (MIC 8-16 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2-85 µM

Target

Target Organism Staphylococcus aureus CIP 677 MRSA

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2-4 µM

Target

Target Organism Klebsiella pneumoniae CIP 8291

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

cremoris I 116 (MIC < 0.125 uM), S. aureus CIP 677 MRSA (MIC 2-85 uM), Gram- E. coli L2, K. pneumoniae CIP 8291 (MIC 2-4 uM), P. putida LMA (16-32 uM), and S. enterica CIP 813 (MIC 8-16 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8-16 µM

Target

Target Organism S. enterica CIP 813

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

uM), Gram- E. coli L2, K. pneumoniae CIP 8291 (MIC 2-4 uM), P. putida LMA (16-32 uM), and S. enterica CIP 813 (MIC 8-16 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2-85 µM

Target

Target Organism Staphylococcus aureus CIP 677 MRSA

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2-4 µM

Target

Target Organism Klebsiella pneumoniae CIP 8291

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

cremoris I 116 (MIC < 0.125 uM), S. aureus CIP 677 MRSA (MIC 2-85 uM), Gram- E. coli L2, K. pneumoniae CIP 8291 (MIC 2-4 uM), P. putida LMA (16-32 uM), and S. enterica CIP 813 (MIC 8-16 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8-16 µM

Target

Target Organism S. enterica CIP 813

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

uM), Gram- E. coli L2, K. pneumoniae CIP 8291 (MIC 2-4 uM), P. putida LMA (16-32 uM), and S. enterica CIP 813 (MIC 8-16 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2-85 µM

Target

Target Organism Staphylococcus aureus CIP 677 MRSA

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2-4 µM

Target

Target Organism Klebsiella pneumoniae CIP 8291

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

cremoris I 116 (MIC < 0.125 uM), S. aureus CIP 677 MRSA (MIC 2-85 uM), Gram- E. coli L2, K. pneumoniae CIP 8291 (MIC 2-4 uM), P. putida LMA (16-32 uM), and S. enterica CIP 813 (MIC 8-16 uM).

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8-16 µM

Target

Target Organism S. enterica CIP 813

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

uM), Gram- E. coli L2, K. pneumoniae CIP 8291 (MIC 2-4 uM), P. putida LMA (16-32 uM), and S. enterica CIP 813 (MIC 8-16 uM).

Evidence 13 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. | J Biol Chem | 2001

Evidence 14 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. | J Biol Chem | 2001

Evidence 15 Activity

Activity

Activity Endpoint 50% Cell death

Detail Source Activity Toxicity

Activity Measurement 24.7 µM

Toxicity Type Cytotoxic

Toxicity Raw

50% Cell death | 24.7 | µM | target cell: CEM-SS cells

Target

Target Cell CEM-SS cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Antimicrob Agents Chemother | 2010