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Peptide record

TPDB10417

Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10417
Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antidiabetic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLNALKKVFQGIHEAIKLINNHVQ
Physicochemical Analysis
C122H202N36O32
RDCMPSTWY
NILK
2685.17
10.32
5
1
11
+2
5.41
-0.008
130.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
2
A
0
R
3
N
0
D
0
C
1
E
2
Q
2
G
2
H
3
I
3
L
3
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 3 D: 0 C: 0 E: 1 Q: 2 G: 2 H: 2 I: 3 L: 3 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
24
C122H202N36O32
2685.17
10.32
+2
5.41
-0.008
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 2.5 uM), S. aureus (MIC 80 uM), C.albicans (MIC 130 uM). In addition, this peptide stimulated ins
Evidence 2 Activity

Activity

MIC
Antibacterial
80 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 80 uM), C.albicans (MIC 130 uM). In addition, this peptide stimulated insulin release from the B
Evidence 3 Activity

Activity

MIC
Antibacterial
130 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 80 uM), C.albicans (MIC 130 uM). In addition, this peptide stimulated insulin release from the BRIN-BD11 clonal beta-cell
Evidence 4 Activity

Activity

MIC
Antifungal
2.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 2.5 uM), S. aureus (MIC 80 uM), C.albicans (MIC 130 uM). In addition, this peptide stimulated ins
Evidence 5 Activity

Activity

MIC
Antifungal
80 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 80 uM), C.albicans (MIC 130 uM). In addition, this peptide stimulated insulin release from the B
Evidence 6 Activity

Activity

MIC
Antifungal
130 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 80 uM), C.albicans (MIC 130 uM). In addition, this peptide stimulated insulin release from the BRIN-BD11 clonal beta-cell
Evidence 7 Activity

Activity

MIC
Antiparasitic
2.5 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 2.5 uM), S. aureus (MIC 80 uM), C.albicans (MIC 130 uM). In addition, this peptide stimulated ins
Evidence 8 Activity

Activity

MIC
Antiparasitic
80 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 80 uM), C.albicans (MIC 130 uM). In addition, this peptide stimulated insulin release from the B
Evidence 9 Activity

Activity

MIC
Antiparasitic
130 µM

Target

C.albicans

Source & Reference

DRAMP

Other

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 80 uM), C.albicans (MIC 130 uM). In addition, this peptide stimulated insulin release from the BRIN-BD11 clonal beta-cell
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
50% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Computational design of highly selective antimicrobial peptides. | J Chem Inf Model | 2009
Evidence 11 Activity

Activity

39% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
39% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A plausible mode of action of pseudin-2, an antimicrobial peptide from Pseudis paradoxa. | Biochim Biophys Acta | 2011
Evidence 12 Activity

Activity

32% Cell death
Toxicity
64 µM
Cytotoxic
32% Cell death | 64 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Improved Cell Selectivity of Pseudin-2 via Substitution in the Leucine-Zipper Motif: In Vitro and In Vivo Antifungal Activity. | Antibiotics (Basel) | 2020
Evidence 13 Activity

Activity

40%Cell death
Toxicity
128 µM
Cytotoxic
40%Cell death | 128 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Improved Cell Selectivity of Pseudin-2 via Substitution in the Leucine-Zipper Motif: In Vitro and In Vivo Antifungal Activity. | Antibiotics (Basel) | 2020
Evidence 14 Activity

Activity

79% Cell death
Toxicity
256 µM
Cytotoxic
79% Cell death | 256 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Improved Cell Selectivity of Pseudin-2 via Substitution in the Leucine-Zipper Motif: In Vitro and In Vivo Antifungal Activity. | Antibiotics (Basel) | 2020
Evidence 15 Activity

Activity

0% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
0% Hemolysis | 64 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Improved Cell Selectivity of Pseudin-2 via Substitution in the Leucine-Zipper Motif: In Vitro and In Vivo Antifungal Activity. | Antibiotics (Basel) | 2020
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
360 µM
Hemolytic Cytotoxic
50% Hemolysis | 360 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Pseudin-2: an antimicrobial peptide with low hemolytic activity from the skin of the paradoxical frog. | Biochem Biophys Res Commun | 2001
Evidence 17 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic
Hemolytic_activity: [Ref.11689009]50% hemolysis of human erythrocytes is >300 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2001 Nov 9 288(4):1001-1005.
Evidence 18 Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.