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Peptide record

TPDB10416

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10416
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb dbAMP 3.0 i2APP AI4AVP DRAVP 2.0 CPPsite3.0 MLCPP 2.0 ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
DSHAKRHHGYKRKFHEKHHSHRGY
Physicochemical Analysis
C133H195N51O33
NCQILMPTWV
H
3036.33
10.69
14
2
4
+6
13.46
-2.454
4.17
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
2980
98.14
4
Residue Composition
number
1
A
3
R
0
N
1
D
0
C
1
E
0
Q
2
G
7
H
0
I
0
L
4
K
0
M
1
F
0
P
2
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 2 H: 7 I: 0 L: 0 K: 4 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
24
C133H195N51O33
3036.33
10.69
+6
13.46
-2.454
Evidence Records 31 records
Evidence 1 Activity

Activity

MIC
Antibacterial
>500 µg/mL

Target

C.albicans 315 or B311

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
comitans (ED50 >100 uM), S. mutans cariogenic bacteria (ED50 92 uM). Active against fungi C.albicans 315 or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 3
Evidence 2 Activity

Activity

MIC
Antibacterial
62.5 µg/mL

Target

C. glabrata 359

Source & Reference

dbAMP DRAMP

Other

enic bacteria (ED50 92 uM). Active against fungi C.albicans 315 or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 8072
Evidence 3 Activity

Activity

MIC
Antibacterial
500 µg/mL

Target

C.krusei 355

Source & Reference

dbAMP DRAMP

Other

against fungi C.albicans 315 or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof
Evidence 4 Activity

Activity

MIC
Antibacterial
31.3 µg/mL

Target

C. neoformans 316

Source & Reference

dbAMP DRAMP

Other

or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof et al., 2000 ). S. cerevisiae (MIC
Evidence 5 Activity

Activity

MIC
Antibacterial
>500 µg/mL

Target

A.fumigatus X 807219

Source & Reference

dbAMP DRAMP

Other

9 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof et al., 2000 ). S. cerevisiae (MIC 74 uM) (Data from ref for AP504). It also
Evidence 6 Activity

Activity

MIC
Antibacterial
74 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

16 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof et al., 2000 ). S. cerevisiae (MIC 74 uM) (Data from ref for AP504). It also inhibits intracellular L. donovani ( Luque-Ortega et a
Evidence 7 Activity

Activity

MIC
Antifungal
>500 µg/mL

Target

C.albicans 315 or B311

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
comitans (ED50 >100 uM), S. mutans cariogenic bacteria (ED50 92 uM). Active against fungi C.albicans 315 or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 3
Evidence 8 Activity

Activity

MIC
Antifungal
62.5 µg/mL

Target

C. glabrata 359

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

enic bacteria (ED50 92 uM). Active against fungi C.albicans 315 or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 8072
Evidence 9 Activity

Activity

MIC
Antifungal
500 µg/mL

Target

C.krusei 355

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

against fungi C.albicans 315 or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof
Evidence 10 Activity

Activity

MIC
Antifungal
31.3 µg/mL

Target

C. neoformans 316

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof et al., 2000 ). S. cerevisiae (MIC
Evidence 11 Activity

Activity

MIC
Antifungal
>500 µg/mL

Target

A.fumigatus X 807219

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

9 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof et al., 2000 ). S. cerevisiae (MIC 74 uM) (Data from ref for AP504). It also
Evidence 12 Activity

Activity

MIC
Antifungal
74 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

16 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof et al., 2000 ). S. cerevisiae (MIC 74 uM) (Data from ref for AP504). It also inhibits intracellular L. donovani ( Luque-Ortega et a
Evidence 13 Activity

Activity

MIC
Antiparasitic
>500 µg/mL

Target

C.albicans 315 or B311

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
comitans (ED50 >100 uM), S. mutans cariogenic bacteria (ED50 92 uM). Active against fungi C.albicans 315 or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 3
Evidence 14 Activity

Activity

MIC
Antiparasitic
62.5 µg/mL

Target

C. glabrata 359

Source & Reference

dbAMP 3.0 DRAMP

Other

enic bacteria (ED50 92 uM). Active against fungi C.albicans 315 or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 8072
Evidence 15 Activity

Activity

MIC
Antiparasitic
500 µg/mL

Target

C.krusei 355

Source & Reference

dbAMP 3.0 DRAMP

Other

against fungi C.albicans 315 or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof
Evidence 16 Activity

Activity

MIC
Antiparasitic
31.3 µg/mL

Target

C. neoformans 316

Source & Reference

dbAMP 3.0 DRAMP

Other

or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof et al., 2000 ). S. cerevisiae (MIC
Evidence 17 Activity

Activity

MIC
Antiparasitic
>500 µg/mL

Target

A.fumigatus X 807219

Source & Reference

dbAMP 3.0 DRAMP

Other

9 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof et al., 2000 ). S. cerevisiae (MIC 74 uM) (Data from ref for AP504). It also
Evidence 18 Activity

Activity

MIC
Antiparasitic
74 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0 DRAMP

Other

16 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof et al., 2000 ). S. cerevisiae (MIC 74 uM) (Data from ref for AP504). It also inhibits intracellular L. donovani ( Luque-Ortega et a
Evidence 19 Activity

Activity

MIC
Antiviral
>500 µg/mL

Target

C.albicans 315 or B311

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
comitans (ED50 >100 uM), S. mutans cariogenic bacteria (ED50 92 uM). Active against fungi C.albicans 315 or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 3
Evidence 20 Activity

Activity

MIC
Antiviral
62.5 µg/mL

Target

C. glabrata 359

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

enic bacteria (ED50 92 uM). Active against fungi C.albicans 315 or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 8072
Evidence 21 Activity

Activity

MIC
Antiviral
500 µg/mL

Target

C.krusei 355

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

against fungi C.albicans 315 or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof
Evidence 22 Activity

Activity

MIC
Antiviral
31.3 µg/mL

Target

C. neoformans 316

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

or B311 (MIC >500 ug/ml), C. glabrata 359 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof et al., 2000 ). S. cerevisiae (MIC
Evidence 23 Activity

Activity

MIC
Antiviral
>500 µg/mL

Target

A.fumigatus X 807219

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

9 (MIC 62.5 ug/ml), C.krusei 355 (MIC 500 ug/ml), C. neoformans 316 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof et al., 2000 ). S. cerevisiae (MIC 74 uM) (Data from ref for AP504). It also
Evidence 24 Activity

Activity

MIC
Antiviral
74 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

16 (MIC 31.3 ug/ml), and A.fumigatus X 807219 (MIC>500 ug/ml) ( van't Hof et al., 2000 ). S. cerevisiae (MIC 74 uM) (Data from ref for AP504). It also inhibits intracellular L. donovani ( Luque-Ortega et a
Evidence 25 Activity

Activity

50% Hemolysis
Toxicity
49±9.0 µM
Hemolytic Cytotoxic
50% Hemolysis | 49±9.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides | FEBS Lett | 1999
Evidence 26 Activity

Activity

50% Hemolysis
Toxicity
>66 µM
Hemolytic Cytotoxic
50% Hemolysis | >66 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides | FEBS Lett | 1999
Evidence 27 Activity

Activity

50% Hemolysis
Toxicity
36±4.0 µM
Hemolytic Cytotoxic
50% Hemolysis | 36±4.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides | FEBS Lett | 1999
Evidence 28 Activity

Activity

50% Hemolysis
Toxicity
39±1.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 39±1.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides | FEBS Lett | 1999
Evidence 29 Activity

Activity

1.6±0.6% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
1.6±0.6% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro. | Gene | 2018
Evidence 30 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Antifungal Activity and Action Mechanism of Histatin 5-Halocidin Hybrid Peptides against Candida ssp. | PLoS One | 2016
Evidence 31 Activity

Activity

50% Cell death
Toxicity
>200 µg/mL
Cytotoxic
50% Cell death | >200 | µg/mL | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Antifungal Activity and Action Mechanism of Histatin 5-Halocidin Hybrid Peptides against Candida ssp. | PLoS One | 2016