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Peptide record

TPDB10414

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

24 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10414

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLPVVAGLAAKVLPSIICAVTKKC

FASTA

>TPDB10414|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=24
FLPVVAGLAAKVLPSIICAVTKKC

Formula C114H197N27O27S2

Absent Amino Acids RNDEQHMWY

Common Amino Acids AV

Mass 2442.10

PI 9.80

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 14

Net Charge +3

Boman Index -0.16

Hydrophobicity 1.475

Aliphatic Index 146.25

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 5.12

Polar Residues 4

number

Amino Acid Distribution

A: 4 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 3 K: 3 M: 0 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 4

Length

Formula

C114H197N27O27S2

Mass

2442.10

9.80

Net Charge

Boman Index

-0.16

Hydrophobicity

1.475

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 45 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli (MIC 45 uM) and S. aureus (MIC 7 uM). Also active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.ente

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 45 uM) and S. aureus (MIC 7 uM). Also active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC >128 ug/ml),

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8-16 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 45 uM) and S. aureus (MIC 7 uM). Also active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC >128 ug/ml), and S. aureus ATCC 29213 (MIC 4-8 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.enteritidis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

45 uM) and S. aureus (MIC 7 uM). Also active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC >128 ug/ml), and S. aureus ATCC 29213 (MIC 4-8 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4-8 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 29213

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

o active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC >128 ug/ml), and S. aureus ATCC 29213 (MIC 4-8 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 45 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli (MIC 45 uM) and S. aureus (MIC 7 uM). Also active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.ente

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 7 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against E. coli (MIC 45 uM) and S. aureus (MIC 7 uM). Also active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC >128 ug/ml),

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8-16 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against E. coli (MIC 45 uM) and S. aureus (MIC 7 uM). Also active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC >128 ug/ml), and S. aureus ATCC 29213 (MIC 4-8 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >128 µg/mL

Target

Target Organism S.enteritidis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

45 uM) and S. aureus (MIC 7 uM). Also active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC >128 ug/ml), and S. aureus ATCC 29213 (MIC 4-8 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4-8 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 29213

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

o active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC >128 ug/ml), and S. aureus ATCC 29213 (MIC 4-8 ug/ml).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 45 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli (MIC 45 uM) and S. aureus (MIC 7 uM). Also active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.ente

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 7 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 45 uM) and S. aureus (MIC 7 uM). Also active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC >128 ug/ml),

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8-16 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 45 uM) and S. aureus (MIC 7 uM). Also active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC >128 ug/ml), and S. aureus ATCC 29213 (MIC 4-8 ug/ml).

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >128 µg/mL

Target

Target Organism S.enteritidis

Source & Reference

Database Source DRAMP

Other

Evidence Text

45 uM) and S. aureus (MIC 7 uM). Also active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC >128 ug/ml), and S. aureus ATCC 29213 (MIC 4-8 ug/ml).

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4-8 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 29213

Source & Reference

Database Source DRAMP

Other

Evidence Text

o active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC >128 ug/ml), and S. aureus ATCC 29213 (MIC 4-8 ug/ml).

Evidence 16 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64-128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 64-128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects. | Antibiotics (Basel) | 2022