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Peptide record

TPDB10406

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard

24 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10406

Activity

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP APD_complete APD_hemolytic PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.

Sequence

KLGFENFLVKALKTVMHVPTSPLL

FASTA

>TPDB10406|Antibacterial;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=24
KLGFENFLVKALKTVMHVPTSPLL

Formula C127H208N30O31S1

Absent Amino Acids RDCQIWY

Common Amino Acids L

Mass 2683.29

PI 10.32

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 12

Net Charge +2

Boman Index 2.44

Hydrophobicity 0.550

Aliphatic Index 121.67

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 4

number

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 1 I: 0 L: 5 K: 3 M: 1 F: 2 P: 2 S: 1 T: 2 W: 0 Y: 0 V: 3

Length

Formula

C127H208N30O31S1

Mass

2683.29

10.32

Net Charge

Boman Index

2.44

Hydrophobicity

0.550

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 4 uM), yeast S.

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >256 µM

Target

Target Organism P.aeruginosa

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 4 uM), yeast S. cerevisiae (MIC 64 uM), and

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >256 µM

Target

Target Organism S.aureus

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 4 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 16-2

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP

Other

Evidence Text

inst Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 4 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 16-256 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µM

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP

Other

Evidence Text

M), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 4 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 16-256 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 4 uM), yeast S.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >256 µM

Target

Target Organism P.aeruginosa

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 4 uM), yeast S. cerevisiae (MIC 64 uM), and

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >256 µM

Target

Target Organism S.aureus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 4 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 16-2

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

inst Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 4 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 16-256 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 64 µM

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

M), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 4 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 16-256 uM).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 16 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0

Other

Source Activity Label	Source Definition
Antiparasitic	dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 4 uM), yeast S.

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >256 µM

Target

Target Organism P.aeruginosa

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 4 uM), yeast S. cerevisiae (MIC 64 uM), and

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >256 µM

Target

Target Organism S.aureus

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 4 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 16-2

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

inst Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 4 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 16-256 uM).

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 64 µM

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

M), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 4 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 16-256 uM).

Evidence 16 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 256 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 256 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013

Evidence 17 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 32-64 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 32-64 | µM | target cell: Mouse splenocytes

Target

Target Cell Mouse splenocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013

Evidence 18 Hemolysis

Source & Reference

source APD_complete APD_hemolytic PD_Hemolysis

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.