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Peptide record

TPDB10404

Antibacterial Antifungal Cell-penetrating Peptides Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10404
Antibacterial Antifungal Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia AFP-GFuse CPPsite3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Antifungal, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
IGKEFKRIVERIKRFLRELVRPLR
Physicochemical Analysis
C140H243N45O31
ANDCQHMSTWY
R
3052.75
12.12
9
3
10
+6
9.62
-0.513
121.67
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
3
E
0
Q
1
G
0
H
3
I
3
L
3
K
0
M
2
F
1
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 3 Q: 0 G: 1 H: 0 I: 3 L: 3 K: 3 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
24
C140H243N45O31
3052.75
12.12
+6
9.62
-0.513
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

Escherichia coli ATCC 8739

Source & Reference

NA

Other

24 h incubation: Active against E. coli ATCC 8739 (MIC 2 uM), P. aeruginosa ATCC 9027 (MIC 3 uM), C. albicans ATCC 10231 (MIC 6 uM), and A. niger ATCC
Evidence 2 Activity

Activity

MIC
Antibacterial
3 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

NA

Other

24 h incubation: Active against E. coli ATCC 8739 (MIC 2 uM), P. aeruginosa ATCC 9027 (MIC 3 uM), C. albicans ATCC 10231 (MIC 6 uM), and A. niger ATCC 14406 (MIC18 uM). Acetylation (XXE)
Evidence 3 Activity

Activity

MIC
Antibacterial
6 µM

Target

Candida albicans ATCC 10231

Source & Reference

NA

Other

ubation: Active against E. coli ATCC 8739 (MIC 2 uM), P. aeruginosa ATCC 9027 (MIC 3 uM), C. albicans ATCC 10231 (MIC 6 uM), and A. niger ATCC 14406 (MIC18 uM). Acetylation (XXE) did not influence peptide activity
Evidence 4 Activity

Activity

MIC
Antibacterial
18 µM

Target

A. niger ATCC 14406

Source & Reference

NA

Other

39 (MIC 2 uM), P. aeruginosa ATCC 9027 (MIC 3 uM), C. albicans ATCC 10231 (MIC 6 uM), and A. niger ATCC 14406 (MIC18 uM). Acetylation (XXE) did not influence peptide activity (see ref). It also inhibited MRSA c
Evidence 5 Activity

Activity

MIC
Antifungal
2 µM

Target

Escherichia coli ATCC 8739

Source & Reference

NA

Other

24 h incubation: Active against E. coli ATCC 8739 (MIC 2 uM), P. aeruginosa ATCC 9027 (MIC 3 uM), C. albicans ATCC 10231 (MIC 6 uM), and A. niger ATCC
Evidence 6 Activity

Activity

MIC
Antifungal
3 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

NA

Other

24 h incubation: Active against E. coli ATCC 8739 (MIC 2 uM), P. aeruginosa ATCC 9027 (MIC 3 uM), C. albicans ATCC 10231 (MIC 6 uM), and A. niger ATCC 14406 (MIC18 uM). Acetylation (XXE)
Evidence 7 Activity

Activity

MIC
Antifungal
6 µM

Target

Candida albicans ATCC 10231

Source & Reference

NA

Other

ubation: Active against E. coli ATCC 8739 (MIC 2 uM), P. aeruginosa ATCC 9027 (MIC 3 uM), C. albicans ATCC 10231 (MIC 6 uM), and A. niger ATCC 14406 (MIC18 uM). Acetylation (XXE) did not influence peptide activity
Evidence 8 Activity

Activity

MIC
Antifungal
18 µM

Target

A. niger ATCC 14406

Source & Reference

NA

Other

39 (MIC 2 uM), P. aeruginosa ATCC 9027 (MIC 3 uM), C. albicans ATCC 10231 (MIC 6 uM), and A. niger ATCC 14406 (MIC18 uM). Acetylation (XXE) did not influence peptide activity (see ref). It also inhibited MRSA c
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
>512 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >512 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Discovering highly potent antimicrobial peptides with deep generative model HydrAMP. | Nat Commun | 2023