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Peptide record

TPDB10403

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10403
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
GWLPTFGKILRKAMQLGPKLIQPI
Physicochemical Analysis
C129H213N33O28S1
NDCEHSYV
L
2706.37
11.73
4
0
11
+4
-0.09
0.183
117.92
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
203.22
3
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
2
Q
3
G
0
H
3
I
4
L
3
K
1
M
1
F
3
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 3 L: 4 K: 3 M: 1 F: 1 P: 3 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
24
C129H213N33O28S1
2706.37
11.73
+4
-0.09
0.183
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1-2 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E. coli (MIC 1-2 uM), P. aeruginosa (MIC 8-16 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 1 uM), yeast S.
Evidence 2 Activity

Activity

MIC
Antibacterial
8-16 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 1-2 uM), P. aeruginosa (MIC 8-16 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 1 uM), yeast S. cerevisiae (MIC 32 uM), and
Evidence 3 Activity

Activity

MIC
Antibacterial
16 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 1-2 uM), P. aeruginosa (MIC 8-16 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 1 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-4
Evidence 4 Activity

Activity

MIC
Antibacterial
1 µM

Target

M. luteus

Source & Reference

dbAMP

Other

nst Gram- E. coli (MIC 1-2 uM), P. aeruginosa (MIC 8-16 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 1 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-4 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
32 µM

Target

S. cerevisiae

Source & Reference

dbAMP

Other

M), P. aeruginosa (MIC 8-16 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 1 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-4 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
1-2 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- E. coli (MIC 1-2 uM), P. aeruginosa (MIC 8-16 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 1 uM), yeast S.
Evidence 7 Activity

Activity

MIC
Antifungal
8-16 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 1-2 uM), P. aeruginosa (MIC 8-16 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 1 uM), yeast S. cerevisiae (MIC 32 uM), and
Evidence 8 Activity

Activity

MIC
Antifungal
16 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 1-2 uM), P. aeruginosa (MIC 8-16 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 1 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-4
Evidence 9 Activity

Activity

MIC
Antifungal
1 µM

Target

M. luteus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

nst Gram- E. coli (MIC 1-2 uM), P. aeruginosa (MIC 8-16 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 1 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-4 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
32 µM

Target

S. cerevisiae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

M), P. aeruginosa (MIC 8-16 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 1 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-4 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
1-2 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram- E. coli (MIC 1-2 uM), P. aeruginosa (MIC 8-16 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 1 uM), yeast S.
Evidence 12 Activity

Activity

MIC
Antiparasitic
8-16 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 1-2 uM), P. aeruginosa (MIC 8-16 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 1 uM), yeast S. cerevisiae (MIC 32 uM), and
Evidence 13 Activity

Activity

MIC
Antiparasitic
16 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 1-2 uM), P. aeruginosa (MIC 8-16 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 1 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-4
Evidence 14 Activity

Activity

MIC
Antiparasitic
1 µM

Target

M. luteus

Source & Reference

dbAMP 3.0

Other

nst Gram- E. coli (MIC 1-2 uM), P. aeruginosa (MIC 8-16 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 1 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-4 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
32 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0

Other

M), P. aeruginosa (MIC 8-16 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 1 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-4 uM).
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
50% Hemolysis | 128 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 17 Activity

Activity

IC50
Toxicity
8-16 µM
Cytotoxic
IC50 | 8-16 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 18 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.