Back to search

Peptide record

TPDB10402

Antibacterial Antifungal Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10402
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FWGALAKGALKLIPSLVSSFTKKD
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C123H197N29O31
RNCEQHMY
LK
2578.09
10.55
4
1
12
+3
-0.02
0.392
105.83
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
2.13
4
Residue Composition
number
3
A
0
R
0
N
1
D
0
C
0
E
0
Q
2
G
0
H
1
I
4
L
4
K
0
M
2
F
1
P
3
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 4 K: 4 M: 0 F: 2 P: 1 S: 3 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
24 reviewed residue count
C123H197N29O31 sequence-only estimate (linear, free termini)
2578.09 sequence-only estimate (linear, free termini)
10.55 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
-0.02 sequence-only estimate (linear, free termini)
0.392 sequence-only estimate (linear, free termini)
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
415.8-30 µM

Target

M. luteus AB2010179

Source & Reference

NA

Other

Active against Gram+ B. megaterium AB 90008 M. luteus AB2010179 (MIC 415.8-30 uM) S. aureus AB 94004 (MIC 5.6 uM) E. coli DH5alpha, P. fluorences PF, P. putida PP (MIC 1
Evidence 2 Activity

Activity

MIC
Antibacterial
5.6 µM

Target

Staphylococcus aureus AB 94004

Source & Reference

NA

Other

Active against Gram+ B. megaterium AB 90008 M. luteus AB2010179 (MIC 415.8-30 uM) S. aureus AB 94004 (MIC 5.6 uM) E. coli DH5alpha, P. fluorences PF, P. putida PP (MIC 15.8-40 uM), S. enterica AB 201018
Evidence 3 Activity

Activity

MIC
Antibacterial
15.8-40 µM

Target

P. putida PP

Source & Reference

NA

Other

9 (MIC 415.8-30 uM) S. aureus AB 94004 (MIC 5.6 uM) E. coli DH5alpha, P. fluorences PF, P. putida PP (MIC 15.8-40 uM), S. enterica AB 2010185 (MIC 15-40 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
15-40 µM

Target

S. enterica AB 2010185

Source & Reference

NA

Other

AB 94004 (MIC 5.6 uM) E. coli DH5alpha, P. fluorences PF, P. putida PP (MIC 15.8-40 uM), S. enterica AB 2010185 (MIC 15-40 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
415.8-30 µM

Target

M. luteus AB2010179

Source & Reference

Antifungipept

Other

Active against Gram+ B. megaterium AB 90008 M. luteus AB2010179 (MIC 415.8-30 uM) S. aureus AB 94004 (MIC 5.6 uM) E. coli DH5alpha, P. fluorences PF, P. putida PP (MIC 1
Evidence 6 Activity

Activity

MIC
Antifungal
5.6 µM

Target

Staphylococcus aureus AB 94004

Source & Reference

Antifungipept

Other

Active against Gram+ B. megaterium AB 90008 M. luteus AB2010179 (MIC 415.8-30 uM) S. aureus AB 94004 (MIC 5.6 uM) E. coli DH5alpha, P. fluorences PF, P. putida PP (MIC 15.8-40 uM), S. enterica AB 201018
Evidence 7 Activity

Activity

MIC
Antifungal
15.8-40 µM

Target

P. putida PP

Source & Reference

Antifungipept

Other

9 (MIC 415.8-30 uM) S. aureus AB 94004 (MIC 5.6 uM) E. coli DH5alpha, P. fluorences PF, P. putida PP (MIC 15.8-40 uM), S. enterica AB 2010185 (MIC 15-40 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
15-40 µM

Target

S. enterica AB 2010185

Source & Reference

Antifungipept

Other

AB 94004 (MIC 5.6 uM) E. coli DH5alpha, P. fluorences PF, P. putida PP (MIC 15.8-40 uM), S. enterica AB 2010185 (MIC 15-40 uM).
Evidence 9 Activity

Activity

2% Hemolysis
Toxicity
0.8 µM
Hemolytic Cytotoxic
2% Hemolysis | 0.8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. | Peptides | 2014
Evidence 10 Activity

Activity

10.6% Hemolysis
Toxicity
1.6 µM
Hemolytic Cytotoxic
10.6% Hemolysis | 1.6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. | Peptides | 2014
Evidence 11 Activity

Activity

49.3% Hemolysis
Toxicity
3.2 µM
Hemolytic Cytotoxic
49.3% Hemolysis | 3.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. | Peptides | 2014
Evidence 12 Activity

Activity

94% Hemolysis
Toxicity
6.4 µM
Hemolytic Cytotoxic
94% Hemolysis | 6.4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. | Peptides | 2014
Evidence 13 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.