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Peptide record

TPDB10400

Antibacterial Antifungal Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10400
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
FLPAVLKVAAHILPTAICAISRRC
Physicochemical Analysis
C117H199N33O27S2
NDEQGMWY
A
2564.19
10.12
4
0
14
+3
-0.19
1.221
142.50
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.87
4
Residue Composition
number
5
A
2
R
0
N
0
D
2
C
0
E
0
Q
0
G
1
H
3
I
3
L
1
K
0
M
1
F
2
P
1
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 5 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 1 I: 3 L: 3 K: 1 M: 0 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
24
C117H199N33O27S2
2564.19
10.12
+3
-0.19
1.221
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus ATCC 25923 (MIC 3.1 uM), E. faecium 091299 (IS) (MIC 50 uM), E. faecalis 981 (IS) (MIC 3.1 uM), N. asteroides 201
Evidence 2 Activity

Activity

MIC
Antibacterial
>400 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP

Other

C >400 uM), K.Pneumoniae 08040724 (IS) (MIC >400 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E.coli ATCC 25922 (MIC >400 uM), P. faecalis X29 (IS) (MIC 25 uM), C. glabrata 090902 (IS) (MIC 12.5 uM), C.albicans ATCC
Evidence 3 Activity

Activity

MIC
Antibacterial
>400 µM

Target

C.albicans ATCC10231

Source & Reference

dbAMP

Other

2 (MIC >400 uM), P. faecalis X29 (IS) (MIC 25 uM), C. glabrata 090902 (IS) (MIC 12.5 uM), C.albicans ATCC10231 (MIC>400 uM). IS= Isolated strain.
Evidence 4 Activity

Activity

MIC
Antifungal
3.1 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus ATCC 25923 (MIC 3.1 uM), E. faecium 091299 (IS) (MIC 50 uM), E. faecalis 981 (IS) (MIC 3.1 uM), N. asteroides 201
Evidence 5 Activity

Activity

MIC
Antifungal
>400 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

C >400 uM), K.Pneumoniae 08040724 (IS) (MIC >400 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E.coli ATCC 25922 (MIC >400 uM), P. faecalis X29 (IS) (MIC 25 uM), C. glabrata 090902 (IS) (MIC 12.5 uM), C.albicans ATCC
Evidence 6 Activity

Activity

MIC
Antifungal
>400 µM

Target

C.albicans ATCC10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

2 (MIC >400 uM), P. faecalis X29 (IS) (MIC 25 uM), C. glabrata 090902 (IS) (MIC 12.5 uM), C.albicans ATCC10231 (MIC>400 uM). IS= Isolated strain.
Evidence 7 Activity

Activity

11% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
11% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 8 Activity

Activity

30% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
30% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
50% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 10 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.