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Peptide record

TPDB10389

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10389
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLGAIAGVAAKFLPKVFCFITKKC
Physicochemical Analysis
C125H198N28O26S2
RNDEQHMSWY
AKF
2573.24
10.17
4
0
14
+4
-2.71
1.238
105.83
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.86
3
Residue Composition
number
4
A
0
R
0
N
0
D
2
C
0
E
0
Q
2
G
0
H
2
I
2
L
4
K
0
M
4
F
1
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 2 K: 4 M: 0 F: 4 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
24
C125H198N28O26S2
2573.24
10.17
+4
-2.71
1.238
Evidence Records 4 records
Evidence 1 Activity

Activity

LC50
Hemolysis
8 mM
[Ref.19379837] LC50=8 mM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug 150(2):150-154.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
50% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae). | Comp Biochem Physiol C Toxicol Pharmacol | 2009
Evidence 3 Activity

Activity

LC50
Toxicity
8 mM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.19379837] LC50=8 mM against human erythrocytes | Cytotoxicity: [Ref.19379837] LC50=4mM against HepG2 hepatoma-derived cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug 150(2):150-154.
Evidence 4 Hemolysis

Activity

8 mM
LC50
[Ref.19379837] LC50=8 mM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

HemoPI PD_Hemolysis
Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug 150(2):150-154.
DRAMP4
PD_Hemolysis