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Peptide record

TPDB10383

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10383
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPAVIRVAANVLPTVFCAISKKC
Physicochemical Analysis
C119H198N30O28S2
DEQGHMWY
AV
2561.19
9.92
3
0
14
+3
-0.50
1.279
130.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.88
5
Residue Composition
number
4
A
1
R
1
N
0
D
2
C
0
E
0
Q
0
G
0
H
2
I
2
L
2
K
0
M
2
F
2
P
1
S
1
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 2 K: 2 M: 0 F: 2 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 4
Chemical Descriptors
24
C119H198N30O28S2
2561.19
9.92
+3
-0.50
1.279
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 50 uM), S. aureus MRSA (MIC 6-13 uM), and C. albicans (MIC 50 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
6-13 µM

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 50 uM), S. aureus MRSA (MIC 6-13 uM), and C. albicans (MIC 50 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
50 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 50 uM), S. aureus MRSA (MIC 6-13 uM), and C. albicans (MIC 50 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
50 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 50 uM), S. aureus MRSA (MIC 6-13 uM), and C. albicans (MIC 50 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
6-13 µM

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 50 uM), S. aureus MRSA (MIC 6-13 uM), and C. albicans (MIC 50 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
50 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 50 uM), S. aureus MRSA (MIC 6-13 uM), and C. albicans (MIC 50 uM).
Evidence 7 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 50 uM), S. aureus MRSA (MIC 6-13 uM), and C. albicans (MIC 50 uM).
Evidence 8 Activity

Activity

MIC
Antiparasitic
6-13 µM

Target

Staphylococcus aureus MRSA

Source & Reference

DRAMP

Other

Active against E. coli (MIC 50 uM), S. aureus MRSA (MIC 6-13 uM), and C. albicans (MIC 50 uM).
Evidence 9 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

Active against E. coli (MIC 50 uM), S. aureus MRSA (MIC 6-13 uM), and C. albicans (MIC 50 uM).
Evidence 10 Activity

Activity

% Hemolysis
Hemolysis
6.8 %
[Ref.22917879] It has 79.2 ± 6.8% hemolytic activity at 128 µg/mL against rabbit red blood cells

Target

rabbit red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
J Proteomics. 2012 Oct 22 75(18):5807-5821.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 11 Activity

Activity

79% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
79% Hemolysis | 128 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: de novo sequencing and analysis of tandem mass spectrometry data. | J Proteomics | 2012
Evidence 12 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.22917879] It has 79.2 ± 6.8% hemolytic activity at 128 µg/mL against rabbit red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Proteomics. 2012 Oct 22 75(18):5807-5821.
Evidence 13 Hemolysis

Activity

6.8 %
% Hemolysis
[Ref.22917879] It has 79.2 ± 6.8% hemolytic activity at 128 µg/mL against rabbit red blood cells
Hemolysis

Target

rabbit red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
J Proteomics. 2012 Oct 22 75(18):5807-5821.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.