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Peptide record

TPDB10378

Antibacterial Anticancer Antiviral Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10378
Antibacterial Anticancer Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AI4AVP, and other sources, with an available 3D structural model.
Sequence
TLLKKVLKAAAKAALNAVLVGANA
Physicochemical Analysis
C107H194N30O28
RDCEQHIMFPSWY
A
2348.90
11.00
4
0
16
+4
1.00
0.929
150.83
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
8
A
0
R
2
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
5
L
4
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 8 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 5 K: 4 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
24
C107H194N30O28
2348.90
11.00
+4
1.00
0.929
Evidence Records 5 records
Evidence 1 Activity

Activity

57.1±7.64% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
57.1±7.64% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evaluating the effect of dermaseptin S4 and its derivatives on multidrug-resistant bacterial strains and on the colon cancer cell line SW620. | Environ Sci Pollut Res Int | 2021
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
16.5±0.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 16.5±0.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity | J Biol Chem | 2000
Evidence 3 Activity

Activity

50% Cytotoxicity
Toxicity
34 µM
Cytotoxic
50% Cytotoxicity | 34 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
In Vitro Antiviral Activity of Dermaseptin S(4) and Derivatives From Amphibian Skin Against Herpes Simplex Virus Type 2 | J Med Virol | 2013
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.23161023]Vero cells:CC50=34 µM.

Source & Reference

NA
DRAMP
J Med Virol. 2013 Feb 85(2):272-81.
Evidence 5 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis