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Peptide record

TPDB10370

Antibacterial Antifungal Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10370
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
FLPAIIGMAAKVLPAFLCKITKKC
Physicochemical Analysis
C122H206N28O26S3
RNDEQHSWY
AK
2577.33
10.17
4
0
14
+4
-1.18
1.204
126.25
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.85
3
Residue Composition
number
4
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
3
I
3
L
4
K
1
M
2
F
2
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 3 K: 4 M: 1 F: 2 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
24
C122H206N28O26S3
2577.33
10.17
+4
-1.18
1.204
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4.7 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus ATCC 25923 (MIC 4.7 uM), E. faecalis 981 (MIC 9.4 uM), N. asteroides 201118 (MIC 1.2 uM), P. aeruginosa CGMCC 1.5
Evidence 2 Activity

Activity

MIC
Antibacterial
9.4 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP

Other

Active against S. aureus ATCC 25923 (MIC 4.7 uM), E. faecalis 981 (MIC 9.4 uM), N. asteroides 201118 (MIC 1.2 uM), P. aeruginosa CGMCC 1.50, K. pneumoniae 08040724 (MIC
Evidence 3 Activity

Activity

MIC
Antibacterial
1.2 µM

Target

N. asteroides 201118

Source & Reference

dbAMP

Other

Active against S. aureus ATCC 25923 (MIC 4.7 uM), E. faecalis 981 (MIC 9.4 uM), N. asteroides 201118 (MIC 1.2 uM), P. aeruginosa CGMCC 1.50, K. pneumoniae 08040724 (MIC 75 uM), E. coli ATCC 25922, C.albi
Evidence 4 Activity

Activity

MIC
Antibacterial
75 µM

Target

Klebsiella pneumoniae 08040724

Source & Reference

dbAMP

Other

. faecalis 981 (MIC 9.4 uM), N. asteroides 201118 (MIC 1.2 uM), P. aeruginosa CGMCC 1.50, K. pneumoniae 08040724 (MIC 75 uM), E. coli ATCC 25922, C.albicans ATCC 10231, and C. glabrata 090902 (MIC 37.5 uM). Updated
Evidence 5 Activity

Activity

MIC
Antibacterial
37.5 µM

Target

C. glabrata 090902

Source & Reference

dbAMP

Other

1.50, K. pneumoniae 08040724 (MIC 75 uM), E. coli ATCC 25922, C.albicans ATCC 10231, and C. glabrata 090902 (MIC 37.5 uM). Updated 5/2019 7/2021
Evidence 6 Activity

Activity

MIC
Antifungal
4.7 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus ATCC 25923 (MIC 4.7 uM), E. faecalis 981 (MIC 9.4 uM), N. asteroides 201118 (MIC 1.2 uM), P. aeruginosa CGMCC 1.5
Evidence 7 Activity

Activity

MIC
Antifungal
9.4 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 4.7 uM), E. faecalis 981 (MIC 9.4 uM), N. asteroides 201118 (MIC 1.2 uM), P. aeruginosa CGMCC 1.50, K. pneumoniae 08040724 (MIC
Evidence 8 Activity

Activity

MIC
Antifungal
1.2 µM

Target

N. asteroides 201118

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 4.7 uM), E. faecalis 981 (MIC 9.4 uM), N. asteroides 201118 (MIC 1.2 uM), P. aeruginosa CGMCC 1.50, K. pneumoniae 08040724 (MIC 75 uM), E. coli ATCC 25922, C.albi
Evidence 9 Activity

Activity

MIC
Antifungal
75 µM

Target

Klebsiella pneumoniae 08040724

Source & Reference

dbAMP CAFPdb Antifungipept

Other

. faecalis 981 (MIC 9.4 uM), N. asteroides 201118 (MIC 1.2 uM), P. aeruginosa CGMCC 1.50, K. pneumoniae 08040724 (MIC 75 uM), E. coli ATCC 25922, C.albicans ATCC 10231, and C. glabrata 090902 (MIC 37.5 uM). Updated
Evidence 10 Activity

Activity

MIC
Antifungal
37.5 µM

Target

C. glabrata 090902

Source & Reference

dbAMP CAFPdb Antifungipept

Other

1.50, K. pneumoniae 08040724 (MIC 75 uM), E. coli ATCC 25922, C.albicans ATCC 10231, and C. glabrata 090902 (MIC 37.5 uM). Updated 5/2019 7/2021
Evidence 11 Activity

Activity

61.8% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
61.8% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 12 Activity

Activity

61.3% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
61.3% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 13 Activity

Activity

60.6% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
60.6% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 14 Activity

Activity

46.0% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
46.0% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 15 Activity

Activity

38.1% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
38.1% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 16 Activity

Activity

10.2% Hemolysis
Toxicity
6.3 µM
Hemolytic Cytotoxic
10.2% Hemolysis | 6.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 17 Activity

Activity

0% Hemolysis
Toxicity
3.1 µM
Hemolytic Cytotoxic
0% Hemolysis | 3.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 18 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.